HCSGD entry for MCM3
1. General information
| Official gene symbol | MCM3 |
|---|---|
| Entrez ID | 4172 |
| Gene full name | minichromosome maintenance complex component 3 |
| Other gene symbols | HCC5 P1-MCM3 P1.h RLFB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003678 | DNA helicase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005658 | Alpha DNA polymerase:primase complex | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006260 | DNA replication | IEA TAS | biological_process |
| GO:0006270 | DNA replication initiation | IEA | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0042555 | MCM complex | IDA IEA | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9839921280 | 0.0005006915 | 0.9999902473 | 0.0411834375 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0979359194 |
| GSE13712_SHEAR | Down | -0.5744645061 |
| GSE13712_STATIC | Up | 0.0508312795 |
| GSE19018 | Down | -0.3684026810 |
| GSE19899_A1 | Down | -0.8124129819 |
| GSE19899_A2 | Down | -2.9219550153 |
| PubMed_21979375_A1 | Down | -1.3889926331 |
| PubMed_21979375_A2 | Down | -3.0501991874 |
| GSE35957 | Down | -2.0468746996 |
| GSE36640 | Down | -3.1789404111 |
| GSE54402 | Down | -0.2284271917 |
| GSE9593 | Down | -1.6416266413 |
| GSE43922 | Down | -1.1272982132 |
| GSE24585 | Up | 0.0222537147 |
| GSE37065 | Down | -0.1893887599 |
| GSE28863_A1 | Up | 0.1431665121 |
| GSE28863_A2 | Up | 0.6391791870 |
| GSE28863_A3 | Down | -0.0265174266 |
| GSE28863_A4 | Down | -0.0483135797 |
| GSE48662 | Down | -0.9020402882 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016314 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-1 | MIMAT0000416 | MIRT023522 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024312 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025232 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026151 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026151 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028827 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038726 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-5p | MIMAT0000689 | MIRT044198 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046726 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049183 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052696 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
