HCSGD entry for MCM2
1. General information
| Official gene symbol | MCM2 |
|---|---|
| Entrez ID | 4171 |
| Gene full name | minichromosome maintenance complex component 2 |
| Other gene symbols | BM28 CCNL1 CDCL1 D3S3194 MITOTIN cdc19 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000785 | Chromatin | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA TAS | molecular_function |
| GO:0003678 | DNA helicase activity | IEA | molecular_function |
| GO:0003688 | DNA replication origin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005664 | Nuclear origin of replication recognition complex | IEA | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006268 | DNA unwinding involved in DNA replication | IEA | biological_process |
| GO:0006270 | DNA replication initiation | IEA IMP | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0006334 | Nucleosome assembly | IEA | biological_process |
| GO:0007049 | Cell cycle | TAS | biological_process |
| GO:0042393 | Histone binding | IEA | molecular_function |
| GO:0042555 | MCM complex | IDA IEA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0071353 | Cellular response to interleukin-4 | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9547290414 | 0.0003488393 | 0.9999902473 | 0.0343832714 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2806591124 |
| GSE13712_SHEAR | Down | -0.3004885781 |
| GSE13712_STATIC | Up | 0.1685324168 |
| GSE19018 | Down | -0.1067950801 |
| GSE19899_A1 | Down | -0.9555503976 |
| GSE19899_A2 | Down | -3.4406540241 |
| PubMed_21979375_A1 | Down | -1.4824082910 |
| PubMed_21979375_A2 | Down | -2.4304868280 |
| GSE35957 | Down | -2.7663307990 |
| GSE36640 | Down | -4.0711620995 |
| GSE54402 | Down | -0.3648130539 |
| GSE9593 | Down | -1.4191835849 |
| GSE43922 | Down | -0.2709908902 |
| GSE24585 | Up | 0.1292171129 |
| GSE37065 | Down | -0.4376293336 |
| GSE28863_A1 | Down | -0.0094726051 |
| GSE28863_A2 | Up | 1.0336739850 |
| GSE28863_A3 | Down | -0.1037368129 |
| GSE28863_A4 | Down | -0.1072250567 |
| GSE48662 | Down | -0.9807891350 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1296-5p | MIMAT0005794 | MIRT000473 | qRT-PCR//Western blot | Functional MTI | 20332239 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT007327 | Luciferase reporter assay | Functional MTI | 23233736 |
| hsa-miR-1 | MIMAT0000416 | MIRT023837 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025400 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036508 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-501-3p | MIMAT0004774 | MIRT037990 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-500a-5p | MIMAT0004773 | MIRT038004 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039755 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042538 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
