HCSGD entry for MC4R

1. General information

Official gene symbolMC4R
Entrez ID4160
Gene full namemelanocortin 4 receptor
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002024Diet induced thermogenesisIEAbiological_process
GO:0004977Melanocortin receptor activityTASmolecular_function
GO:0004980Melanocyte-stimulating hormone receptor activityIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006112Energy reserve metabolic processIEAbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007631Feeding behaviorIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0017046Peptide hormone bindingIEAmolecular_function
GO:0030073Insulin secretionIEAbiological_process
GO:0030819Positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032868Response to insulinIEAbiological_process
GO:0042923Neuropeptide bindingIPImolecular_function
GO:0045780Positive regulation of bone resorptionIMPbiological_process
GO:2000252Negative regulation of feeding behaviorIEAbiological_process
GO:2000821Regulation of grooming behaviorIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49201692940.05137503130.99999024730.4262345936

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0249946021
GSE13712_SHEARDown-0.1603226834
GSE13712_STATICUp0.1381802396
GSE19018Up0.0957187977
GSE19899_A1Up0.2458370710
GSE19899_A2Down-0.2675670837
PubMed_21979375_A1Up0.1206031628
PubMed_21979375_A2Down-0.4727711987
GSE35957Down-0.1857054897
GSE36640Up0.1613147501
GSE54402Down-0.0825706684
GSE9593Up0.1636433570
GSE43922Up0.0165754296
GSE24585Up0.0313053293
GSE37065Down-0.0629474867
GSE28863_A1Down-0.4143798805
GSE28863_A2Up0.1396616161
GSE28863_A3Down-2.8737670031
GSE28863_A4Up0.6379637168
GSE48662Down-0.0413403266

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-877-5pMIMAT0004949MIRT037223CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.