HCSGD entry for MBL2

1. General information

Official gene symbolMBL2
Entrez ID4153
Gene full namemannose-binding lectin (protein C) 2, soluble
Other gene symbolsCOLEC1 HSMBPC MBL MBL2D MBP MBP-C MBP1 MBPD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001867Complement activation, lectin pathwayIDA IPI TASbiological_process
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005537Mannose bindingNAS TASmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005581CollagenIEAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006953Acute-phase responseTASbiological_process
GO:0006956Complement activationTASbiological_process
GO:0006958Complement activation, classical pathwayIEAbiological_process
GO:0006979Response to oxidative stressNASbiological_process
GO:0008228OpsonizationTASbiological_process
GO:0009986Cell surfaceTAScellular_component
GO:0042742Defense response to bacteriumTASbiological_process
GO:0044130Negative regulation of growth of symbiont in hostIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048306Calcium-dependent protein bindingIPImolecular_function
GO:0050766Positive regulation of phagocytosisIEAbiological_process
GO:0050830Defense response to Gram-positive bacteriumIDAbiological_process
GO:0051873Killing by host of symbiont cellsIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.77433850160.75903903730.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0707325549
GSE13712_SHEARDown-0.2495361230
GSE13712_STATICDown-0.0340026985
GSE19018Up0.0623163501
GSE19899_A1Up0.0094060187
GSE19899_A2Down-0.1386643790
PubMed_21979375_A1Up0.2323704075
PubMed_21979375_A2Up0.0440422117
GSE35957Up0.2285159693
GSE36640Down-0.1676147330
GSE54402Down-0.1610291391
GSE9593Up0.2494230245
GSE43922Up0.0138646840
GSE24585Down-0.0053892522
GSE37065Up0.0384739869
GSE28863_A1Up0.0819048961
GSE28863_A2Down-0.1050565055
GSE28863_A3Up0.0905630608
GSE28863_A4Down-0.0407785027
GSE48662Up0.0586690941

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

O3-SulfonylgalactoseDB01818 EXPT02894
Methyl alpha-D-mannosideDB01979 EXPT02195 | DB02284
O4-SulfonylgalactoseDB02837 EXPT01646 | DB03377
beta-L-methyl-fucoseDB03194 EXPT02161
N-acetyl-alpha-neuraminic acidDB03721 EXPT02292 | EXPT02908 | EXPT02909 | DB01894 | DB02344
alpha-L-methyl-fucoseDB03879 EXPT02163 | EXPT02160 | DB04091
Alpha-Methyl-N-Acetyl-D-GlucosamineDB04426 EXPT02108 | DB02612

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22239660We analyzed MBL2 gene variants in two cohorts of centenarians, octo-nonagenarians and nonagenarians, and in the general population, one from Sardinia Island (Italy), recruited in the frame of the AKea study, and another from Campania (southern Italy), to search for haplotypes related to longevity
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