HCSGD entry for MAX
1. General information
| Official gene symbol | MAX |
|---|---|
| Entrez ID | 4149 |
| Gene full name | MYC associated factor X |
| Other gene symbols | bHLHd4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003712 | Transcription cofactor activity | TAS | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006461 | Protein complex assembly | IEA | biological_process |
| GO:0009267 | Cellular response to starvation | IEA | biological_process |
| GO:0010629 | Negative regulation of gene expression | IEA | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
| GO:0048678 | Response to axon injury | IEA | biological_process |
| GO:0051402 | Neuron apoptotic process | IEA | biological_process |
| GO:0060041 | Retina development in camera-type eye | IEA | biological_process |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
| GO:0071375 | Cellular response to peptide hormone stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0391381255 | 0.9837805479 | 0.4461475097 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2853766199 |
| GSE13712_SHEAR | Down | -0.0287616252 |
| GSE13712_STATIC | Up | 0.1575134736 |
| GSE19018 | Down | -0.2009747716 |
| GSE19899_A1 | Up | 0.1305014430 |
| GSE19899_A2 | Up | 1.0738531045 |
| PubMed_21979375_A1 | Up | 0.7471626550 |
| PubMed_21979375_A2 | Up | 0.1789590073 |
| GSE35957 | Up | 0.2571644588 |
| GSE36640 | Up | 0.1463175594 |
| GSE54402 | Up | 0.3550785402 |
| GSE9593 | Up | 0.5248443545 |
| GSE43922 | Up | 0.2365842049 |
| GSE24585 | Down | -0.1510016507 |
| GSE37065 | Up | 0.1784701328 |
| GSE28863_A1 | Up | 0.0693985870 |
| GSE28863_A2 | Up | 0.4208884867 |
| GSE28863_A3 | Up | 0.0321747350 |
| GSE28863_A4 | Down | -0.0218140881 |
| GSE48662 | Up | 0.0210182501 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016436 | Microarray | Functional MTI (Weak) | 20304954 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-22-3p | MIMAT0000077 | NA | hsa-miR-22 | {Western blot} | {overexpression by miRNA precursor transfection} | 20214878 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17640558 | The early observations on the rate-of-living theory by Max Rubner and the report by Gershman that oxygen free radicals exist in vivo culminated in the seminal proposal in the 1950s by Denham Harman that reactive oxygen species are a cause of aging (free radical theory of aging) |
| 16167342 | This loss results in persistent expression of hMad4, which leads to an inability to switch from an hMad4/Max complex to a c-Myc/Max complex on selected c-Myc target genes following serum stimulation |
| 11846374 | Microarray gene screening reveals that quiescent and senescent cells, in comparison with replicating ones, are characterized by downregulation of Pam, a protein associated with c-Myc, and upregulation of Mad family genes, Max dimerization proteins |
| 10606235 | We also found that estrogen activates c-Myc expression in MCF-7 cells and that E-boxes in the hTERT promoter that bind c-Myc/Max play additional roles in estrogen-induced transactivation of hTERT |
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