HCSGD entry for MAF
1. General information
| Official gene symbol | MAF |
|---|---|
| Entrez ID | 4094 |
| Gene full name | v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) |
| Other gene symbols | CCA4 c-MAF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000785 | Chromatin | TAS | cellular_component |
| GO:0001816 | Cytokine production | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0032330 | Regulation of chondrocyte differentiation | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0048468 | Cell development | IEA | biological_process |
| GO:0048839 | Inner ear development | IEA | biological_process |
| GO:0070306 | Lens fiber cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0256529425 | 0.9473699821 | 0.3754387437 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1861273261 |
| GSE13712_SHEAR | Up | 0.0495744499 |
| GSE13712_STATIC | Up | 0.2487911026 |
| GSE19018 | Down | -0.1093227283 |
| GSE19899_A1 | Up | 0.0062955077 |
| GSE19899_A2 | Down | -0.0069103050 |
| PubMed_21979375_A1 | Down | -0.2231506941 |
| PubMed_21979375_A2 | Up | 0.1265265145 |
| GSE35957 | Up | 0.0949211547 |
| GSE36640 | Up | 0.3065350122 |
| GSE54402 | Up | 0.7500487714 |
| GSE9593 | Down | -0.0604390933 |
| GSE43922 | Up | 0.0853647067 |
| GSE24585 | Down | -0.1525195537 |
| GSE37065 | Down | -0.1533595866 |
| GSE28863_A1 | Up | 0.9169461472 |
| GSE28863_A2 | Up | 0.8644516947 |
| GSE28863_A3 | Up | 0.6228882633 |
| GSE28863_A4 | Up | 0.1090733326 |
| GSE48662 | Up | 0.3083504409 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26496036 | These global changes in the transcriptional and functional programs of proliferation, differentiation, and self-renewal were all mediated by ROS-induced suppression of c-Maf, as evidenced by binding of c-Maf to promoter regions of multiple relevant genes in hAMSCs which could be reduced by exogenous ROS |
| 26496036 | Our findings implicate the strong effects of ROS on multiple stem cell functions with a central role for c-Maf in stem cell senescence |
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