HCSGD entry for SMAD2

1. General information

Official gene symbolSMAD2
Entrez ID4087
Gene full nameSMAD family member 2
Other gene symbolsJV18 JV18-1 MADH2 MADR2 hMAD-2 hSMAD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0001657Ureteric bud developmentIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001706Endoderm formationIEAbiological_process
GO:0001707Mesoderm formationIEA ISSbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIEA ISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005160Transforming growth factor beta receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIDA IEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006468Protein phosphorylationIEAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDA IEA IMP TASbiological_process
GO:0007182Common-partner SMAD protein phosphorylationIDAbiological_process
GO:0007183SMAD protein complex assemblyIDAbiological_process
GO:0007352Zygotic specification of dorsal/ventral axisIMPbiological_process
GO:0007369GastrulationTASbiological_process
GO:0008134Transcription factor bindingIEA IPImolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0009880Embryonic pattern specificationIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEA ISSbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIEA ISSbiological_process
GO:0017015Regulation of transforming growth factor beta receptor signaling pathwayIMPbiological_process
GO:0019902Phosphatase bindingIPImolecular_function
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030073Insulin secretionIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIMPbiological_process
GO:0030618Transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityIDAmolecular_function
GO:0031016Pancreas developmentIEAbiological_process
GO:0031053Primary miRNA processingTASbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032444Activin responsive factor complexIDAcellular_component
GO:0032924Activin receptor signaling pathwayIMPbiological_process
GO:0033613Activating transcription factor bindingIPImolecular_function
GO:0034713Type I transforming growth factor beta receptor bindingIPImolecular_function
GO:0035265Organ growthIEAbiological_process
GO:0035556Intracellular signal transductionIEA ISSbiological_process
GO:0038092Nodal signaling pathwayIMPbiological_process
GO:0045165Cell fate commitmentIEA ISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMP ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISS TASbiological_process
GO:0046332SMAD bindingIEA IPImolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048340Paraxial mesoderm morphogenesisIEA ISSbiological_process
GO:0048589Developmental growthIEAbiological_process
GO:0048617Embryonic foregut morphogenesisIEAbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0051098Regulation of bindingIEA ISSbiological_process
GO:0060021Palate developmentIEA ISSbiological_process
GO:0060039Pericardium developmentIEAbiological_process
GO:0070410Co-SMAD bindingIPImolecular_function
GO:0070411I-SMAD bindingIPImolecular_function
GO:0070412R-SMAD bindingIPImolecular_function
GO:0070723Response to cholesterolIDAbiological_process
GO:0071141SMAD protein complexIDAcellular_component
GO:1900224Positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91498049090.04412978610.99999024730.3949473308

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0421084562
GSE13712_SHEARDown-0.0559127483
GSE13712_STATICDown-0.0226228508
GSE19018Up0.2400645275
GSE19899_A1Down-0.2638366816
GSE19899_A2Down-0.4354511569
PubMed_21979375_A1Down-0.9976717797
PubMed_21979375_A2Down-0.3666851331
GSE35957Up0.1457617677
GSE36640Down-0.3613869168
GSE54402Down-0.2319087268
GSE9593Up0.1522643696
GSE43922Down-0.7753261264
GSE24585Down-0.2888295873
GSE37065Down-0.1485445161
GSE28863_A1Up0.7914040683
GSE28863_A2Up0.3112427071
GSE28863_A3Down-0.2018359833
GSE28863_A4Down-0.1473474867
GSE48662Down-0.4637800666

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PhosphonoserineDB04522 EXPT02883

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT005872Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blotFunctional MTI21036908
hsa-miR-155-5pMIMAT0000646MIRT005872Reporter assay;OtherFunctional MTI20584899
hsa-miR-200a-3pMIMAT0000682MIRT007290Luciferase reporter assayFunctional MTI22020340
hsa-miR-200b-3pMIMAT0000318MIRT007322Luciferase reporter assayFunctional MTI23492772
hsa-miR-652-3pMIMAT0003322MIRT039468CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042141CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043212CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT0000646NAhsa-miR-155{Western blot}{overexpression by miRNA mimics tranfection}19650740
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15356634These cells also have impaired phosphorylation and nuclear translocation of the TGF-beta signalling proteins Smad2 and Smad3, as well as impaired induction of TGF-beta target genes
15356634Furthermore, cytoplasmic PML physically interacts with Smad2/3 and SARA (Smad anchor for receptor activation) and is required for association of Smad2/3 with SARA and for the accumulation of SARA and TGF-beta receptor in the early endosome
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