HCSGD entry for SMAD1

1. General information

Official gene symbolSMAD1
Entrez ID4086
Gene full nameSMAD family member 1
Other gene symbolsBSP-1 BSP1 JV4-1 JV41 MADH1 MADR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIEAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0001657Ureteric bud developmentIEAbiological_process
GO:0001710Mesodermal cell fate commitmentIEAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0002051Osteoblast fate commitmentIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005057Receptor signaling protein activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularNAScellular_component
GO:0005634NucleusIDA IEA NAS TAScellular_component
GO:0005637Nuclear inner membraneIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006468Protein phosphorylationIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEA NASbiological_process
GO:0007183SMAD protein complex assemblyIDAbiological_process
GO:0007276Gamete generationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009880Embryonic pattern specificationISSbiological_process
GO:0010243Response to organonitrogen compoundIEAbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010656Negative regulation of muscle cell apoptotic processIEAbiological_process
GO:0016021Integral component of membraneNAScellular_component
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030509BMP signaling pathwayIDA IMP ISS TASbiological_process
GO:0030618Transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityTASmolecular_function
GO:0030901Midbrain developmentIEAbiological_process
GO:0030902Hindbrain developmentIEAbiological_process
GO:0031053Primary miRNA processingTASbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042592Homeostatic processIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterICbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050775Positive regulation of dendrite morphogenesisIEAbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0060038Cardiac muscle cell proliferationIEAbiological_process
GO:0060348Bone developmentIEAbiological_process
GO:0061036Positive regulation of cartilage developmentIEAbiological_process
GO:0070410Co-SMAD bindingIPImolecular_function
GO:0070411I-SMAD bindingIPImolecular_function
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0071773Cellular response to BMP stimulusIEA ISSbiological_process
GO:1901522Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05374331140.04067756160.50539036400.3802230387

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2911135714
GSE13712_SHEARUp0.0239477432
GSE13712_STATICDown-0.6393497608
GSE19018Down-0.3590580440
GSE19899_A1Up0.6711612894
GSE19899_A2Up1.0004418437
PubMed_21979375_A1Up2.0219021954
PubMed_21979375_A2Up1.7040895044
GSE35957Down-0.4548488901
GSE36640Down-1.0527324536
GSE54402Down-0.1092873814
GSE9593Down-0.5652331203
GSE43922Up0.8673893024
GSE24585Down-0.5679641058
GSE37065Up0.0875671768
GSE28863_A1Up0.1911229853
GSE28863_A2Down-0.7012108437
GSE28863_A3Down-0.6943404782
GSE28863_A4Down-0.2344269689
GSE48662Up0.1578068753

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30d-5pMIMAT0000245MIRT006322Luciferase reporter assay//Western blotFunctional MTI22253433
hsa-miR-30c-5pMIMAT0000244MIRT006321Luciferase reporter assay//Western blotFunctional MTI22253433
hsa-miR-30a-5pMIMAT0000087MIRT006319Luciferase reporter assay//Western blotFunctional MTI22253433
hsa-miR-155-5pMIMAT0000646MIRT001500Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20427544
hsa-miR-155-5pMIMAT0000646MIRT001500pSILAC//ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26a-5pMIMAT0000082MIRT002340Western blotFunctional MTI20857419
hsa-miR-26a-5pMIMAT0000082MIRT002340RNase mapping analysis//Western blot//Reporter assayFunctional MTI17922609
hsa-miR-26a-5pMIMAT0000082MIRT002340Luciferase reporter assayFunctional MTI14697198
hsa-miR-26a-5pMIMAT0000082MIRT002340Luciferase reporter assay//Western blot//Reporter assayFunctional MTI18197755
hsa-miR-26a-5pMIMAT0000082MIRT002340Luciferase reporter assayFunctional MTI23028144
hsa-miR-30b-5pMIMAT0000420MIRT006320Luciferase reporter assay//Western blotFunctional MTI22253433
hsa-miR-16-5pMIMAT0000069MIRT031384ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-26a-5pMIMAT00000822hsa-miR-26a14697198
hsa-miR-26a-5pMIMAT00000821hsa-miR-26a14697198
hsa-miR-26a-5pMIMAT0000082NAhsa-miR-26a{Western blot}{Western blot}{N/A}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}18197755
hsa-miR-26a-5pMIMAT0000082NAhsa-miR-26a{Western blot}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}17922609
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22072987Ras-activated cells senesced with nuclear accumulation of phosphorylated SMAD1/5/8
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