HCSGD entry for MAD2L1

1. General information

Official gene symbolMAD2L1
Entrez ID4085
Gene full nameMAD2 mitotic arrest deficient-like 1 (yeast)
Other gene symbolsHSMAD2 MAD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000070Mitotic sister chromatid segregationIEAbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000776KinetochoreIDAcellular_component
GO:0000777Condensed chromosome kinetochoreIEAcellular_component
GO:0000922Spindle poleIEAcellular_component
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005643Nuclear poreIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0007093Mitotic cell cycle checkpointIDAbiological_process
GO:0007094Mitotic spindle assembly checkpointTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0042177Negative regulation of protein catabolic processIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0060564Negative regulation of mitotic anaphase-promoting complex activityIDAbiological_process
GO:0072686Mitotic spindleIDAcellular_component
GO:0090267Positive regulation of mitotic cell cycle spindle assembly checkpointIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99407550620.00004954980.99999024730.0114692982

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.5387319673
GSE13712_SHEARUp0.0604203229
GSE13712_STATICDown-0.1138088109
GSE19018Down-0.0031239917
GSE19899_A1Down-1.4811803210
GSE19899_A2Down-2.5119968278
PubMed_21979375_A1Down-1.3986155384
PubMed_21979375_A2Down-3.8743162750
GSE35957Down-2.7952993333
GSE36640Down-4.1847044240
GSE54402Down-0.6182712876
GSE9593Down-1.4562978711
GSE43922Down-1.2159449871
GSE24585Down-0.4273985622
GSE37065Down-0.3166666705
GSE28863_A1Down-0.1387013689
GSE28863_A2Up0.3203453458
GSE28863_A3Down-0.1850445184
GSE28863_A4Up0.0446206576
GSE48662Down-2.1961531238

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004853Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blot;Microarray;OtherFunctional MTI19074876
hsa-miR-1MIMAT0000416MIRT023679Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-215-5pMIMAT0000272MIRT024623MicroarrayFunctional MTI (Weak)19074876
hsa-miR-93-5pMIMAT0000093MIRT048838CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.