HCSGD entry for ARRB1

1. General information

Official gene symbolARRB1
Entrez ID408
Gene full namearrestin, beta 1
Other gene symbolsARB1 ARR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0000785ChromatinIDAcellular_component
GO:0001934Positive regulation of protein phosphorylationIMPbiological_process
GO:0002031G-protein coupled receptor internalizationIMPbiological_process
GO:0002092Positive regulation of receptor internalizationIMPbiological_process
GO:0004402Histone acetyltransferase activityIDAmolecular_function
GO:0004857Enzyme inhibitor activityTASmolecular_function
GO:0005096GTPase activator activityIMPmolecular_function
GO:0005159Insulin-like growth factor receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005765Lysosomal membraneTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005834Heterotrimeric G-protein complexTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005905Coated pitIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIMPbiological_process
GO:0006892Post-Golgi vesicle-mediated transportTASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007602PhototransductionIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0015031Protein transportIEAbiological_process
GO:0016567Protein ubiquitinationIMPbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030659Cytoplasmic vesicle membraneTAScellular_component
GO:0031143PseudopodiumIEAcellular_component
GO:0031397Negative regulation of protein ubiquitinationIDAbiological_process
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0031434Mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0031701Angiotensin receptor bindingIPImolecular_function
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032092Positive regulation of protein bindingIEAbiological_process
GO:0032715Negative regulation of interleukin-6 productionIDAbiological_process
GO:0032717Negative regulation of interleukin-8 productionIDAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIEAbiological_process
GO:0035025Positive regulation of Rho protein signal transductionIMPbiological_process
GO:0035066Positive regulation of histone acetylationIMPbiological_process
GO:0035774Positive regulation of insulin secretion involved in cellular response to glucose stimulusIEAbiological_process
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processIEAmolecular_function
GO:0043085Positive regulation of catalytic activityIMPbiological_process
GO:0043149Stress fiber assemblyIMPbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0043547Positive regulation of GTPase activityIMPbiological_process
GO:0044212Transcription regulatory region DNA bindingIMPmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0090240Positive regulation of histone H4 acetylationIMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02152741920.77045990270.35340286781.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0429773794
GSE13712_SHEARDown-1.1391139176
GSE13712_STATICDown-1.4393064539
GSE19018Up0.0041465538
GSE19899_A1Up0.1534522007
GSE19899_A2Up0.7211542196
PubMed_21979375_A1Up1.2327249755
PubMed_21979375_A2Up0.4753061968
GSE35957Up0.1124788837
GSE36640Up1.4011123509
GSE54402Up0.3625470391
GSE9593Up0.0801564019
GSE43922Up0.8572414619
GSE24585Up0.1552708982
GSE37065Up0.1332771229
GSE28863_A1Up0.3131120944
GSE28863_A2Up0.6254537838
GSE28863_A3Down-0.3044554464
GSE28863_A4Up0.0552322287
GSE48662Up0.0404896034

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016808MicroarrayFunctional MTI (Weak)18185580
hsa-miR-98-5pMIMAT0000096MIRT027412MicroarrayFunctional MTI (Weak)19088304
hsa-miR-26b-5pMIMAT0000083MIRT028751MicroarrayFunctional MTI (Weak)19088304
hsa-miR-186-5pMIMAT0000456MIRT045162CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049191CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.