| 25323119 | Here, we investigated the significance and molecular mechanisms of microRNA-22 (miR-22) governing EPC senescence |
| 25323119 | RESULTS: We found that miR-22 was upregulated in aged EPCs |
| 25323119 | Overexpression of miR-22 in young EPCs induced cell senescence, decreased proliferation and migration, and impaired angiogenesis in vitro |
| 25323119 | Conversely, silencing of endogenous miR-22 led to decreased cell senescence, increased proliferation and migration, and improved angiogenesis |
| 25323119 | AKT3 was identified as a direct target of miR-22, and restoration of AKT3 expression attenuated the effects of miR-22 in young EPCs |
| 25323119 | CONCLUSION: Our results indicate that miR-22 induces EPC senescence by downregulating AKT3 expression, providing a potential novel target for the reversal of EPC dysfunction in angiogenesis |
| 22538858 | MiR-22 was most prominently upregulated during cardiac aging |
| 22538858 | Luciferase reporter assays validated mimecan as a bona fide miR-22 target |
| 22538858 | Both, miR-22 and its target mimecan were co- expressed in cardiac fibroblasts and smooth muscle cells |
| 22538858 | Functionally, miR-22 overexpression induced cellular senescence and promoted migratory activity of cardiac fibroblasts |
| 22538858 | Rescue experiments revealed that the effects of miR-22 on cardiac fibroblasts were only partially mediated by mimecan |
| 22538858 | In conclusion, miR-22 upregulation in the aging heart contributed at least partly to accelerated cardiac fibroblast senescence and increased migratory activity |
| 22538858 | Our results suggest an involvement of miR-22 in age-associated cardiac changes, such as cardiac fibrosis |
| 21502362 | Here, we report that miR-22, a novel SA-miRNA, has an impact on tumorigenesis |
| 21502362 | Synthetic miR-22 delivery suppresses tumor growth and metastasis in vivo by inducing cellular senescence in a mouse model of breast carcinoma |
| 21502362 | Our study provides the first evidence that miR-22 restores the cellular senescence program in cancer cells and acts as a tumor suppressor |
