HCSGD entry for LYN
1. General information
| Official gene symbol | LYN |
|---|---|
| Entrez ID | 4067 |
| Gene full name | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog |
| Other gene symbols | JTK8 p53Lyn p56Lyn |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001782 | B cell homeostasis | IEA ISS | biological_process |
| GO:0001817 | Regulation of cytokine production | ISS | biological_process |
| GO:0001932 | Regulation of protein phosphorylation | TAS | biological_process |
| GO:0001933 | Negative regulation of protein phosphorylation | ISS | biological_process |
| GO:0002431 | Fc receptor mediated stimulatory signaling pathway | IEA ISS | biological_process |
| GO:0002513 | Tolerance induction to self antigen | IEA ISS TAS | biological_process |
| GO:0002553 | Histamine secretion by mast cell | IEA | biological_process |
| GO:0002576 | Platelet degranulation | IEA ISS | biological_process |
| GO:0002762 | Negative regulation of myeloid leukocyte differentiation | IEA | biological_process |
| GO:0002768 | Immune response-regulating cell surface receptor signaling pathway | ISS TAS | biological_process |
| GO:0002774 | Fc receptor mediated inhibitory signaling pathway | IEA ISS | biological_process |
| GO:0002902 | Regulation of B cell apoptotic process | IEA | biological_process |
| GO:0004713 | Protein tyrosine kinase activity | EXP IDA IEA TAS | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | TAS | molecular_function |
| GO:0004716 | Receptor signaling protein tyrosine kinase activity | TAS | molecular_function |
| GO:0005161 | Platelet-derived growth factor receptor binding | IEA | molecular_function |
| GO:0005178 | Integrin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA ISS | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0006991 | Response to sterol depletion | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | IMP | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | ISS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IMP | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IC | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0009725 | Response to hormone | ISS | biological_process |
| GO:0009743 | Response to carbohydrate | IEA | biological_process |
| GO:0010976 | Positive regulation of neuron projection development | IMP | biological_process |
| GO:0014003 | Oligodendrocyte development | IEA | biological_process |
| GO:0014069 | Postsynaptic density | IEA | cellular_component |
| GO:0014070 | Response to organic cyclic compound | IEA | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0023014 | Signal transduction by phosphorylation | TAS | biological_process |
| GO:0030061 | Mitochondrial crista | IEA | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030218 | Erythrocyte differentiation | IEA ISS | biological_process |
| GO:0030262 | Apoptotic nuclear changes | IDA | biological_process |
| GO:0030335 | Positive regulation of cell migration | IEA | biological_process |
| GO:0030889 | Negative regulation of B cell proliferation | IEA | biological_process |
| GO:0031175 | Neuron projection development | IEA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0031663 | Lipopolysaccharide-mediated signaling pathway | IEA ISS | biological_process |
| GO:0031668 | Cellular response to extracellular stimulus | IEA | biological_process |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0033003 | Regulation of mast cell activation | ISS | biological_process |
| GO:0033628 | Regulation of cell adhesion mediated by integrin | IMP | biological_process |
| GO:0034136 | Negative regulation of toll-like receptor 2 signaling pathway | IEA ISS | biological_process |
| GO:0034144 | Negative regulation of toll-like receptor 4 signaling pathway | IEA ISS | biological_process |
| GO:0034605 | Cellular response to heat | IEA | biological_process |
| GO:0034666 | Alpha2-beta1 integrin complex | IEA | cellular_component |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0042531 | Positive regulation of tyrosine phosphorylation of STAT protein | IEA ISS | biological_process |
| GO:0042629 | Mast cell granule | IEA | cellular_component |
| GO:0043200 | Response to amino acid | IEA | biological_process |
| GO:0043208 | Glycosphingolipid binding | IEA | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0043304 | Regulation of mast cell degranulation | IEA ISS | biological_process |
| GO:0043407 | Negative regulation of MAP kinase activity | IEA ISS | biological_process |
| GO:0043552 | Positive regulation of phosphatidylinositol 3-kinase activity | IEA | biological_process |
| GO:0044325 | Ion channel binding | IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045121 | Membrane raft | IDA IEA | cellular_component |
| GO:0045646 | Regulation of erythrocyte differentiation | IEA ISS | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0048678 | Response to axon injury | IEA | biological_process |
| GO:0050663 | Cytokine secretion | IEA | biological_process |
| GO:0050707 | Regulation of cytokine secretion | IEA | biological_process |
| GO:0050727 | Regulation of inflammatory response | IEA | biological_process |
| GO:0050777 | Negative regulation of immune response | TAS | biological_process |
| GO:0050853 | B cell receptor signaling pathway | IEA | biological_process |
| GO:0050855 | Regulation of B cell receptor signaling pathway | IEA ISS | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0051219 | Phosphoprotein binding | IEA | molecular_function |
| GO:0051272 | Positive regulation of cellular component movement | IDA | biological_process |
| GO:0051279 | Regulation of release of sequestered calcium ion into cytosol | IEA | biological_process |
| GO:0060252 | Positive regulation of glial cell proliferation | IEA | biological_process |
| GO:0060369 | Positive regulation of Fc receptor mediated stimulatory signaling pathway | IEA | biological_process |
| GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | TAS | biological_process |
| GO:0070304 | Positive regulation of stress-activated protein kinase signaling cascade | IDA | biological_process |
| GO:0070372 | Regulation of ERK1 and ERK2 cascade | ISS | biological_process |
| GO:0070373 | Negative regulation of ERK1 and ERK2 cascade | IEA ISS | biological_process |
| GO:0070447 | Positive regulation of oligodendrocyte progenitor proliferation | IEA | biological_process |
| GO:0070667 | Negative regulation of mast cell proliferation | IEA ISS | biological_process |
| GO:0070668 | Positive regulation of mast cell proliferation | IMP | biological_process |
| GO:0071300 | Cellular response to retinoic acid | IMP | biological_process |
| GO:0090025 | Regulation of monocyte chemotaxis | IMP | biological_process |
| GO:0090330 | Regulation of platelet aggregation | IEA ISS | biological_process |
| GO:0097028 | Dendritic cell differentiation | IEA ISS | biological_process |
| GO:1902532 | Negative regulation of intracellular signal transduction | ISS | biological_process |
| GO:2000670 | Positive regulation of dendritic cell apoptotic process | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0427558034 | 0.0235473842 | 0.4615978261 | 0.2958362118 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2360841830 |
| GSE13712_SHEAR | Down | -1.3202578160 |
| GSE13712_STATIC | Down | -1.1499823204 |
| GSE19018 | Down | -0.0549718439 |
| GSE19899_A1 | Down | -0.0659234415 |
| GSE19899_A2 | Up | 1.7353345091 |
| PubMed_21979375_A1 | Up | 1.6061485975 |
| PubMed_21979375_A2 | Up | 1.3566425455 |
| GSE35957 | Up | 0.2987767087 |
| GSE36640 | Down | -0.3849130863 |
| GSE54402 | Up | 0.9850251664 |
| GSE9593 | Up | 0.2861106500 |
| GSE43922 | Up | 0.4570104230 |
| GSE24585 | Down | -0.6430858455 |
| GSE37065 | Up | 0.6760736114 |
| GSE28863_A1 | Down | -0.5441809203 |
| GSE28863_A2 | Down | -0.4445199035 |
| GSE28863_A3 | Down | -0.6493734434 |
| GSE28863_A4 | Down | -0.3226458342 |
| GSE48662 | Down | -0.2666194071 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine | DB03023 | EXPT02634 |
| Bosutinib | DB06616 | - |
| Ponatinib | DB08901 | - |
| Nintedanib | DB09079 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-222-3p | MIMAT0000279 | MIRT046575 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22926520 | Expression of the SFK v-Src, Hck or Lyn together with STAT5A results in phosphorylation on Y694 and cytoplasmic retention |
| 22926520 | Upon coexpression of BCR-ABL and individual SFK the cytoplasmic retention of activated STAT5A mediated by v-Src and Hck but not Lyn is dominant over nuclear translocation induced by BCR-ABL |
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