HCSGD entry for LTC4S
1. General information
| Official gene symbol | LTC4S |
|---|---|
| Entrez ID | 4056 |
| Gene full name | leukotriene C4 synthase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004364 | Glutathione transferase activity | IBA | molecular_function |
| GO:0004464 | Leukotriene-C4 synthase activity | IDA | molecular_function |
| GO:0004602 | Glutathione peroxidase activity | IBA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005635 | Nuclear envelope | IDA TAS | cellular_component |
| GO:0005640 | Nuclear outer membrane | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0006691 | Leukotriene metabolic process | IDA TAS | biological_process |
| GO:0008047 | Enzyme activator activity | IEA | molecular_function |
| GO:0008289 | Lipid binding | IDA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0019370 | Leukotriene biosynthetic process | IBA | biological_process |
| GO:0019372 | Lipoxygenase pathway | TAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | TAS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | IBA | biological_process |
| GO:2001300 | Lipoxin metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6870361460 | 0.3193103188 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0647999877 |
| GSE13712_SHEAR | Down | -1.0709448056 |
| GSE13712_STATIC | Up | 0.0627485509 |
| GSE19018 | Up | 0.0121301081 |
| GSE19899_A1 | Up | 0.0580168101 |
| GSE19899_A2 | Up | 0.2568523479 |
| PubMed_21979375_A1 | Down | -0.2661941878 |
| PubMed_21979375_A2 | Down | -0.0664279899 |
| GSE35957 | Up | 0.0851360937 |
| GSE36640 | Up | 0.0448029768 |
| GSE54402 | Up | 0.0072160396 |
| GSE9593 | Down | -0.0399243775 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.2377862368 |
| GSE28863_A2 | Down | -0.1503042492 |
| GSE28863_A3 | Up | 0.5579505301 |
| GSE28863_A4 | Up | 0.0615811496 |
| GSE48662 | Down | -0.1156016388 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glutathione | DB00143 | NUTR00029 | EXPT01650 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016938 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
