HCSGD entry for LTA4H
1. General information
| Official gene symbol | LTA4H |
|---|---|
| Entrez ID | 4048 |
| Gene full name | leukotriene A4 hydrolase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004177 | Aminopeptidase activity | IDA | molecular_function |
| GO:0004301 | Epoxide hydrolase activity | IDA TAS | molecular_function |
| GO:0004463 | Leukotriene-A4 hydrolase activity | IDA TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006691 | Leukotriene metabolic process | TAS | biological_process |
| GO:0006954 | Inflammatory response | NAS | biological_process |
| GO:0008233 | Peptidase activity | TAS | molecular_function |
| GO:0008237 | Metallopeptidase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IDA IEA | molecular_function |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0019370 | Leukotriene biosynthetic process | IDA | biological_process |
| GO:0043171 | Peptide catabolic process | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4166908818 | 0.1580860378 | 0.9999902473 | 0.7682294443 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1182137058 |
| GSE13712_SHEAR | Down | -0.9692296026 |
| GSE13712_STATIC | Down | -0.6422370020 |
| GSE19018 | Up | 0.7894173430 |
| GSE19899_A1 | Up | 0.1954043964 |
| GSE19899_A2 | Up | 0.2672965254 |
| PubMed_21979375_A1 | Up | 0.3169716857 |
| PubMed_21979375_A2 | Up | 0.1217678719 |
| GSE35957 | Down | -0.0379490251 |
| GSE36640 | Down | -0.0243080643 |
| GSE54402 | Down | -0.3584382199 |
| GSE9593 | Up | 0.0178241731 |
| GSE43922 | Up | 0.1492957352 |
| GSE24585 | Down | -0.1383167592 |
| GSE37065 | Down | -0.1338146900 |
| GSE28863_A1 | Down | -0.0318946380 |
| GSE28863_A2 | Up | 0.1244072777 |
| GSE28863_A3 | Down | -0.7693771888 |
| GSE28863_A4 | Up | 0.1339056349 |
| GSE48662 | Down | -0.0803642582 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine | DB02062 | EXPT00710 |
| 3-(Benzyloxy)Pyridin-2-Amine | DB02352 | EXPT00176 |
| Ubenimex | DB03424 | EXPT00673 |
| DG051 | DB05177 | - |
| CHR-2797 | DB05745 | - |
| 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole | DB06828 | - |
| N-(pyridin-3-ylmethyl)aniline | DB06851 | - |
| (4-fluorophenyl)(pyridin-4-yl)methanone | DB06917 | - |
| 1-(2,2'-bithiophen-5-yl)methanamine | DB07094 | - |
| N-[4-(benzyloxy)phenyl]glycinamide | DB07099 | - |
| (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid | DB07102 | - |
| 4-amino-N-[4-(benzyloxy)phenyl]butanamide | DB07104 | - |
| N-methyl-1-(2-thiophen-2-ylphenyl)methanamine | DB07196 | - |
| {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone | DB07237 | - |
| (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol | DB07258 | - |
| 1-(4-thiophen-2-ylphenyl)methanamine | DB07259 | - |
| N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline | DB07260 | - |
| 4-(2-amino-1,3-thiazol-4-yl)phenol | DB07292 | - |
| N-[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]-L-alanine | DB08040 | - |
| 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol | DB08466 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023123 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030208 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045983 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051821 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052143 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052512 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
