HCSGD entry for LSS
1. General information
| Official gene symbol | LSS |
|---|---|
| Entrez ID | 4047 |
| Gene full name | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) |
| Other gene symbols | OSC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000250 | Lanosterol synthase activity | IEA | molecular_function |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005811 | Lipid particle | IDA | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | IMP TAS | biological_process |
| GO:0008202 | Steroid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0916198929 | 0.5563050606 | 0.6369591125 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1924518151 |
| GSE13712_SHEAR | Up | 0.1792066548 |
| GSE13712_STATIC | Down | -0.1081817797 |
| GSE19018 | Up | 0.1723413626 |
| GSE19899_A1 | Down | -0.0697686133 |
| GSE19899_A2 | Up | 0.5926525754 |
| PubMed_21979375_A1 | Up | 0.2106856621 |
| PubMed_21979375_A2 | Up | 0.6969175560 |
| GSE35957 | Down | -0.0304846676 |
| GSE36640 | Up | 0.7174748257 |
| GSE54402 | Up | 0.0097901362 |
| GSE9593 | Up | 0.5566573187 |
| GSE43922 | Down | -0.2223398976 |
| GSE24585 | Down | -0.4582669754 |
| GSE37065 | Up | 0.1012707392 |
| GSE28863_A1 | Down | -0.0514883808 |
| GSE28863_A2 | Up | 0.7678455213 |
| GSE28863_A3 | Down | -0.4859807013 |
| GSE28863_A4 | Down | -0.0746996056 |
| GSE48662 | Down | -0.0701976697 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018611 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028552 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045991 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047498 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047714 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19409979 | Laminar shear stress (LSS) caused by blood flow is known to regulate endothelial function and to contribute to vascular health |
| 19409979 | In an attempt to identify genes associated with vascular health/disease states, this study assessed the differential gene expression of young and senescent human umbilical vein endothelial cells (HUVECs) under static and LSS conditions |
| 19409979 | Replicative cell senescence was induced by continuous subculture in vitro, and LSS was provided using a cone-and-plate device |
| 19409979 | Young (p4) and senescent (p18) cells were subjected to LSS at 12 dyn |
| 19409979 | The LSS-responsive and senescence-responsive gene groups included 74 genes held in common; these may prove useful for the study of cellular responses commonly affected by LSS and senescence |
| 19409979 | Among them, 20 genes whose expression was increased by LSS and simultaneously decreased by cellular senescence are suggested as potential vascular health markers in the sense that LSS is antiatherogenic, whereas senescence is proatherogenic |
| 19409979 | Furthermore, its diminished expression, and not that of nitric oxide synthase 3, was implicated in the insufficient NO production exhibited by senescent HUVECs under LSS conditions |
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