HCSGD entry for LRP5

1. General information

Official gene symbolLRP5
Entrez ID4041
Gene full namelow density lipoprotein receptor-related protein 5
Other gene symbolsBMND1 EVR1 EVR4 HBM LR3 LRP7 OPPG OPS OPTA1 VBCH2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001702Gastrulation with mouth forming secondIBAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationIMPbiological_process
GO:0002076Osteoblast developmentIBAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006007Glucose catabolic processIMPbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0008217Regulation of blood pressureIMPbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0009952Anterior/posterior pattern specificationIBAbiological_process
GO:0015026Coreceptor activityIBAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0016055Wnt signaling pathwayIDAbiological_process
GO:0017147Wnt-protein bindingIBAmolecular_function
GO:0019534Toxin transporter activityIMPmolecular_function
GO:0030326Embryonic limb morphogenesisIBAbiological_process
GO:0042632Cholesterol homeostasisIMPbiological_process
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0043235Receptor complexIDAcellular_component
GO:0044332Wnt signaling pathway involved in dorsal/ventral axis specificationIDAbiological_process
GO:0045600Positive regulation of fat cell differentiationIMPbiological_process
GO:0045668Negative regulation of osteoblast differentiationIMPbiological_process
GO:0045840Positive regulation of mitosisIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046849Bone remodelingIBAbiological_process
GO:0048539Bone marrow developmentIMPbiological_process
GO:0048596Embryonic camera-type eye morphogenesisIBAbiological_process
GO:0060042Retina morphogenesis in camera-type eyeIMPbiological_process
GO:0060059Embryonic retina morphogenesis in camera-type eyeIBAbiological_process
GO:0060070Canonical Wnt signaling pathwayIDA IMPbiological_process
GO:0060349Bone morphogenesisIMPbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIBAbiological_process
GO:0060612Adipose tissue developmentIMPbiological_process
GO:0060828Regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:0061178Regulation of insulin secretion involved in cellular response to glucose stimulusIBAbiological_process
GO:0061304Retinal blood vessel morphogenesisIMPbiological_process
GO:0071901Negative regulation of protein serine/threonine kinase activityIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70605383530.12542284870.99999024730.6809518977

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2023140451
GSE13712_SHEARDown-0.6206736678
GSE13712_STATICUp0.0590414477
GSE19018Up0.0041737506
GSE19899_A1Down-0.3726965607
GSE19899_A2Up0.2030394148
PubMed_21979375_A1Down-0.5454074194
PubMed_21979375_A2Up0.2201721554
GSE35957Down-0.5737891941
GSE36640Down-0.3060874644
GSE54402Down-0.3353633017
GSE9593Up0.1428350870
GSE43922Up0.0330943705
GSE24585Down-0.2929335885
GSE37065Down-0.2638783897
GSE28863_A1Up0.1392590109
GSE28863_A2Up0.3503174103
GSE28863_A3Up0.2587747263
GSE28863_A4Down-0.0112954648
GSE48662Up0.4892098956

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018508MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.