HCSGD entry for LRP6

1. General information

Official gene symbolLRP6
Entrez ID4040
Gene full namelow density lipoprotein receptor-related protein 6
Other gene symbolsADCAD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001702Gastrulation with mouth forming secondIBAbiological_process
GO:0001843Neural tube closureIBA IEAbiological_process
GO:0001933Negative regulation of protein phosphorylationIMPbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationIEAbiological_process
GO:0003344Pericardium morphogenesisIBA IEAbiological_process
GO:0005041Low-density lipoprotein receptor activityIDAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005109Frizzled bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005769Early endosomeIDA IEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005901CaveolaIDAcellular_component
GO:0006469Negative regulation of protein kinase activityIMPbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007268Synaptic transmissionIBA IEAbiological_process
GO:0009880Embryonic pattern specificationIBA IEAbiological_process
GO:0009950Dorsal/ventral axis specificationIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIBAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0014029Neural crest formationIDAbiological_process
GO:0014033Neural crest cell differentiationIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016055Wnt signaling pathwayIDA IMPbiological_process
GO:0016337Cell-cell adhesionIEAbiological_process
GO:0017147Wnt-protein bindingIEA IPImolecular_function
GO:0019210Kinase inhibitor activityIMPmolecular_function
GO:0019534Toxin transporter activityIMPmolecular_function
GO:0021587Cerebellum morphogenesisIBA IEAbiological_process
GO:0021794Thalamus developmentIBA IEAbiological_process
GO:0021795Cerebral cortex cell migrationIEAbiological_process
GO:0021861Forebrain radial glial cell differentiationIEAbiological_process
GO:0021874Wnt signaling pathway involved in forebrain neuroblast divisionIEAbiological_process
GO:0021943Formation of radial glial scaffoldsIEAbiological_process
GO:0021987Cerebral cortex developmentIBAbiological_process
GO:0030278Regulation of ossificationIBAbiological_process
GO:0030326Embryonic limb morphogenesisIBAbiological_process
GO:0030901Midbrain developmentIBA IEAbiological_process
GO:0030917Midbrain-hindbrain boundary developmentIBA IEAbiological_process
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0034185Apolipoprotein bindingIBAmolecular_function
GO:0034392Negative regulation of smooth muscle cell apoptotic processIMPbiological_process
GO:0035115Embryonic forelimb morphogenesisIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035261External genitalia morphogenesisIBA IEAbiological_process
GO:0036342Post-anal tail morphogenesisIEAbiological_process
GO:0042074Cell migration involved in gastrulationIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIBA IEAbiological_process
GO:0042733Embryonic digit morphogenesisIEAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0043025Neuronal cell bodyIBA IEAcellular_component
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043235Receptor complexIBAcellular_component
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0044332Wnt signaling pathway involved in dorsal/ventral axis specificationIDAbiological_process
GO:0044335Canonical Wnt signaling pathway involved in neural crest cell differentiationICbiological_process
GO:0044340Canonical Wnt signaling pathway involved in regulation of cell proliferationICbiological_process
GO:0045202SynapseIBA IEAcellular_component
GO:0045598Regulation of fat cell differentiationIBAbiological_process
GO:0045599Negative regulation of fat cell differentiationIEAbiological_process
GO:0045778Positive regulation of ossificationIEAbiological_process
GO:0045780Positive regulation of bone resorptionIEAbiological_process
GO:0045787Positive regulation of cell cycleIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046849Bone remodelingIBA IEAbiological_process
GO:0048596Embryonic camera-type eye morphogenesisIBA IEAbiological_process
GO:0048705Skeletal system morphogenesisIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0051593Response to folic acidIEAbiological_process
GO:0060021Palate developmentIBA IEAbiological_process
GO:0060026Convergent extensionIBA IEAbiological_process
GO:0060059Embryonic retina morphogenesis in camera-type eyeIBA IEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIDA IMPbiological_process
GO:0060284Regulation of cell developmentIEAbiological_process
GO:0060325Face morphogenesisIBA IEAbiological_process
GO:0060349Bone morphogenesisIBAbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIBA IEAbiological_process
GO:0060535Trachea cartilage morphogenesisIBA IEAbiological_process
GO:0060596Mammary placode formationIEAbiological_process
GO:0061310Canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart developmentIEAbiological_process
GO:0061324Canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationIEAbiological_process
GO:0071397Cellular response to cholesterolIMPbiological_process
GO:0071542Dopaminergic neuron differentiationIEAbiological_process
GO:0071901Negative regulation of protein serine/threonine kinase activityIDAbiological_process
GO:0071936Coreceptor activity involved in Wnt signaling pathwayIDAmolecular_function
GO:0090009Primitive streak formationIBA IEAbiological_process
GO:0090118Receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportIBA IEAbiological_process
GO:0090244Wnt signaling pathway involved in somitogenesisIBA IEAbiological_process
GO:0090245Axis elongation involved in somitogenesisIBA IEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:1901998Toxin transportIMPbiological_process
GO:2000055Positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specificationIDAbiological_process
GO:2000149Negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesisIEAbiological_process
GO:2000151Negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesisIEAbiological_process
GO:2000162Negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesisIEAbiological_process
GO:2000164Negative regulation of planar cell polarity pathway involved in outflow tract morphogenesisIEAbiological_process
GO:2000166Negative regulation of planar cell polarity pathway involved in pericardium morphogenesisIEAbiological_process
GO:2000168Negative regulation of planar cell polarity pathway involved in neural tube closureIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18212905660.20559083620.83608595570.8800384453

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2196723639
GSE13712_SHEARDown-0.2637356901
GSE13712_STATICUp0.0014339706
GSE19018Down-0.2246245713
GSE19899_A1Up0.0214023305
GSE19899_A2Down-0.2465573381
PubMed_21979375_A1Down-0.5769634260
PubMed_21979375_A2Down-0.2604976706
GSE35957Up0.2074189479
GSE36640Up0.9659329855
GSE54402Down-0.4897143481
GSE9593Up0.1251874265
GSE43922Down-0.1785375641
GSE24585Up0.6854425004
GSE37065Down-0.2404377578
GSE28863_A1Up0.8509758514
GSE28863_A2Up0.7660884404
GSE28863_A3Down-0.1045359221
GSE28863_A4Up0.0186081001
GSE48662Up0.1506892162

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019112MicroarrayFunctional MTI (Weak)18185580
hsa-miR-7-5pMIMAT0000252MIRT025965SequencingFunctional MTI (Weak)20371350
hsa-miR-940MIMAT0004983MIRT036618CLASHFunctional MTI (Weak)23622248
hsa-miR-628-3pMIMAT0003297MIRT039587CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046906CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049446CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050127CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.