HCSGD entry for LPL
1. General information
| Official gene symbol | LPL |
|---|---|
| Entrez ID | 4023 |
| Gene full name | lipoprotein lipase |
| Other gene symbols | HDLCQ11 LIPD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001523 | Retinoid metabolic process | TAS | biological_process |
| GO:0004465 | Lipoprotein lipase activity | IDA IEA ISS | molecular_function |
| GO:0004620 | Phospholipase activity | ISS | molecular_function |
| GO:0004806 | Triglyceride lipase activity | IDA ISS | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006633 | Fatty acid biosynthetic process | IC IDA ISS | biological_process |
| GO:0006641 | Triglyceride metabolic process | ISS | biological_process |
| GO:0006644 | Phospholipid metabolic process | ISS | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008201 | Heparin binding | IDA | molecular_function |
| GO:0009409 | Response to cold | IEA | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0010744 | Positive regulation of macrophage derived foam cell differentiation | IC IEA | biological_process |
| GO:0010886 | Positive regulation of cholesterol storage | IMP | biological_process |
| GO:0010890 | Positive regulation of sequestering of triglyceride | IMP | biological_process |
| GO:0017129 | Triglyceride binding | IEA | molecular_function |
| GO:0019432 | Triglyceride biosynthetic process | IEA | biological_process |
| GO:0019433 | Triglyceride catabolic process | IDA IEA ISS | biological_process |
| GO:0031012 | Extracellular matrix | IEA | cellular_component |
| GO:0031225 | Anchored component of membrane | IEA | cellular_component |
| GO:0034185 | Apolipoprotein binding | IPI | molecular_function |
| GO:0034361 | Very-low-density lipoprotein particle | IEA | cellular_component |
| GO:0034371 | Chylomicron remodeling | IC | biological_process |
| GO:0034372 | Very-low-density lipoprotein particle remodeling | IDA ISS | biological_process |
| GO:0042157 | Lipoprotein metabolic process | TAS | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042627 | Chylomicron | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0070328 | Triglyceride homeostasis | IGI | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0723724745 | 0.6606543292 | 0.5731914612 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0397324554 |
| GSE13712_SHEAR | Up | 0.3021073127 |
| GSE13712_STATIC | Up | 0.3034526502 |
| GSE19018 | Up | 0.0123897689 |
| GSE19899_A1 | Up | 0.1976331623 |
| GSE19899_A2 | Up | 0.2037812112 |
| PubMed_21979375_A1 | Up | 0.2039560631 |
| PubMed_21979375_A2 | Up | 0.1361117380 |
| GSE35957 | Up | 0.0502380184 |
| GSE36640 | Up | 0.0180492196 |
| GSE54402 | Up | 0.6594330460 |
| GSE9593 | Down | -4.7714153578 |
| GSE43922 | Up | 0.0137526095 |
| GSE24585 | Up | 1.0895815682 |
| GSE37065 | Down | -0.0227963086 |
| GSE28863_A1 | Down | -0.0317648030 |
| GSE28863_A2 | Up | 0.0671092453 |
| GSE28863_A3 | Up | 0.2365555446 |
| GSE28863_A4 | Up | 0.1552727948 |
| GSE48662 | Up | 0.0160923503 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001542 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-138-5p | MIMAT0000430 | MIRT005491 | qRT-PCR | Functional MTI (Weak) | 20486779 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT005584 | ELISA//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21276447 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019335 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032343 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27391332 | Finally, during adipocyte differentiation of adipose-derived human mesenchymal stem cells, the expression of adipogenic genes (PPARG, LPIN1, and LPL) increased significantly over 14 days, and noteworthy is that the BSCL2 transcript without exon 7 was differentially expressed by 332 to 723% when compared to day 0, suggesting an underlying role in adipogenesis |
| 23583398 | 7-fold), lipoprotein lipase (3 |
| 20374652 | Key markers of adipogenesis including lipoprotein lipase, FABP4, and Itm2a displayed age-dependent declines |
| 17535427 | In undifferentiated senescent cells, PPARG2 and LPL expression is unaltered, whereas LEP and FABP4 transcript levels are increased but not in all clones |
| 17535427 | Bisulfite sequencing analysis of DNA methylation reveals overall relative stability of LEP, PPARG2, FABP4 and LPL promoter CpG methylation during senescence and upon differentiation |
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