HCSGD entry for LOXL2

1. General information

Official gene symbolLOXL2
Entrez ID4017
Gene full namelysyl oxidase-like 2
Other gene symbolsLOR2 WS9-14
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEA ISSbiological_process
GO:0001837Epithelial to mesenchymal transitionIDAbiological_process
GO:0001935Endothelial cell proliferationIMPbiological_process
GO:0002040Sprouting angiogenesisIMPbiological_process
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003714Transcription corepressor activityIDAmolecular_function
GO:0004720Protein-lysine 6-oxidase activityIDAmolecular_function
GO:0005044Scavenger receptor activityIEAmolecular_function
GO:0005507Copper ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005604Basement membraneIEA ISScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIDA TAScellular_component
GO:0005694ChromosomeIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006464Cellular protein modification processIDAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007568AgingTASbiological_process
GO:0009055Electron carrier activityTASmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016570Histone modificationIDAbiological_process
GO:0018277Protein deaminationIDAbiological_process
GO:0030199Collagen fibril organizationIMPbiological_process
GO:0032332Positive regulation of chondrocyte differentiationIEA ISSbiological_process
GO:0035064Methylated histone residue bindingIDAmolecular_function
GO:0043542Endothelial cell migrationIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0046688Response to copper ionIDAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0070492Oligosaccharide bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75661207780.01022718360.99999024730.2001470632

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5783125017
GSE13712_SHEARDown-0.0177412450
GSE13712_STATICUp0.1430502524
GSE19018Up0.7171745396
GSE19899_A1Down-0.3464683581
GSE19899_A2Down-0.4359071079
PubMed_21979375_A1Down-0.9435126948
PubMed_21979375_A2Down-0.7471793509
GSE35957Up0.2452936460
GSE36640Down-0.0610652572
GSE54402Down-1.0984737609
GSE9593Up0.6322010101
GSE43922Down-0.9127153524
GSE24585Down-0.0425545377
GSE37065Down-0.7570270926
GSE28863_A1Down-0.5005420860
GSE28863_A2Up0.3433669755
GSE28863_A3Down-0.0186641840
GSE28863_A4Down-0.2242720290
GSE48662Up0.1518185071

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004135MicroarrayFunctional MTI (Weak)16822819
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24113189Indeed, in human epithelial cell the constitutive expression of the LOX or LOXL2 protein favored OIS escape, whereas inhibition of lysyl oxidase activity was found to stabilize OIS
11642359However, specific novel functions, such as a potential role in cell adhesion and cell growth control, will be determined by other, conserved domains such as the cytokine receptor-like domain that is shared by all LOXs and by multiple scavenger receptor cysteine-rich (SRCR) domains present in LOXL2 and LOXL3
9079631This full-length cDNA clone of 3432 base pairs (WS9-14) was isolated from human fibroblasts on the basis of its overexpression in senescent cells
9079631The WS9-14 protein has a 48% identity with both lysyl oxidase and lysyl oxidase-like protein at a region corresponding to exons 2-6, implying the existence of a lysyl oxidase gene family
9079631The pattern of WS9-14 gene expression by fibroblasts parallels pro-collagen I-alpha1 expression
9079631WS9-14 is abundantly expressed in all tumor cell lines examined that attach to culture dishes but not in cell lines that grow in suspension and is also up-regulated in senescent fibroblasts
9079631These results suggest that WS9-14 gene encodes an extracellular protein that may be specifically involved in cell adhesion and senescence
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