HCSGD entry for LIMS1
1. General information
| Official gene symbol | LIMS1 |
|---|---|
| Entrez ID | 3987 |
| Gene full name | LIM and senescent cell antigen-like domains 1 |
| Other gene symbols | PINCH PINCH-1 PINCH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0007569 | Cell aging | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IDA IEA | molecular_function |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051291 | Protein heterooligomerization | IEA | biological_process |
| GO:0071560 | Cellular response to transforming growth factor beta stimulus | IEP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6639331484 | 0.5175045211 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2907716649 |
| GSE13712_SHEAR | Up | 0.1575524731 |
| GSE13712_STATIC | Up | 0.2552505061 |
| GSE19018 | Down | -0.0333274086 |
| GSE19899_A1 | Up | 0.1333417856 |
| GSE19899_A2 | Down | -0.1386933354 |
| PubMed_21979375_A1 | Down | -0.2501127547 |
| PubMed_21979375_A2 | Up | 0.1492427767 |
| GSE35957 | Down | -0.1252968706 |
| GSE36640 | Down | -0.0677052529 |
| GSE54402 | Up | 0.1457927667 |
| GSE9593 | Up | 0.0342736042 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.4141159299 |
| GSE28863_A2 | Up | 0.3485928712 |
| GSE28863_A3 | Up | 0.2124377669 |
| GSE28863_A4 | Up | 0.1480911091 |
| GSE48662 | Down | -0.3219276725 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-421 | MIMAT0003339 | MIRT016105 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016188 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019634 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1 | MIMAT0000416 | MIRT023868 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024188 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024835 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026671 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036467 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037466 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040780 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041021 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25346044 | Thus, PINCH-2 participates in decreased systemic recurrence by competitively regulating IPP complex formation with PINCH-1, thereby suppressing autocrine and paracrine effects on motility in colon cancer |
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