HCSGD entry for LIG3
1. General information
| Official gene symbol | LIG3 |
|---|---|
| Entrez ID | 3980 |
| Gene full name | ligase III, DNA, ATP-dependent |
| Other gene symbols | LIG2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000795 | Synaptonemal complex | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003909 | DNA ligase activity | IDA IEA | molecular_function |
| GO:0003910 | DNA ligase (ATP) activity | IBA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005694 | Chromosome | IBA | cellular_component |
| GO:0005739 | Mitochondrion | IBA | cellular_component |
| GO:0006273 | Lagging strand elongation | IBA | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006284 | Base-excision repair | TAS | biological_process |
| GO:0006288 | Base-excision repair, DNA ligation | IEA | biological_process |
| GO:0006289 | Nucleotide-excision repair | IBA | biological_process |
| GO:0006303 | Double-strand break repair via nonhomologous end joining | IEA | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0007131 | Reciprocal meiotic recombination | TAS | biological_process |
| GO:0007283 | Spermatogenesis | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0033151 | V(D)J recombination | IDA | biological_process |
| GO:0043504 | Mitochondrial DNA repair | IEA | biological_process |
| GO:0045910 | Negative regulation of DNA recombination | IEA | biological_process |
| GO:0051103 | DNA ligation involved in DNA repair | IEA | biological_process |
| GO:0051301 | Cell division | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9962715132 | 0.0054899054 | 0.9999902473 | 0.1498960581 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0658165961 |
| GSE13712_SHEAR | Down | -0.3898976859 |
| GSE13712_STATIC | Down | -0.2954112606 |
| GSE19018 | Down | -0.3914969042 |
| GSE19899_A1 | Down | -0.2339640031 |
| GSE19899_A2 | Down | -1.3050683719 |
| PubMed_21979375_A1 | Down | -0.7444056339 |
| PubMed_21979375_A2 | Down | -0.6388824451 |
| GSE35957 | Down | -0.2652458863 |
| GSE36640 | Down | -0.9479046722 |
| GSE54402 | Down | -0.2025634420 |
| GSE9593 | Down | -0.3981270569 |
| GSE43922 | Down | -0.2736144119 |
| GSE24585 | Down | -0.5172409993 |
| GSE37065 | Down | -0.1575437075 |
| GSE28863_A1 | Up | 0.0658029415 |
| GSE28863_A2 | Down | -0.0456794515 |
| GSE28863_A3 | Down | -0.6130183282 |
| GSE28863_A4 | Down | -0.0218379700 |
| GSE48662 | Up | 0.1348025885 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Bleomycin | DB00290 | APRD00453 | EXPT00718 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028636 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045688 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25582120 | Mechanistically, telomere fusions require either the classical non-homologous end-joining (C-NHEJ) pathway dependent on Ku70/80 and LIG4, or the alternative non-homologous end-joining (A-NHEJ), which relies on PARP1 and LIG3 |
| 25582120 | Instead, BRCA1 and CtIP act in the same pathway as LIG3 to promote joining of de-protected telomeres by A-NHEJ |
Entries Per Page
Displaying Page of
