HCSGD entry for LIG1
1. General information
| Official gene symbol | LIG1 |
|---|---|
| Entrez ID | 3978 |
| Gene full name | ligase I, DNA, ATP-dependent |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000722 | Telomere maintenance via recombination | TAS | biological_process |
| GO:0000723 | Telomere maintenance | TAS | biological_process |
| GO:0000724 | Double-strand break repair via homologous recombination | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003909 | DNA ligase activity | IDA | molecular_function |
| GO:0003910 | DNA ligase (ATP) activity | IBA IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005694 | Chromosome | IBA | cellular_component |
| GO:0005739 | Mitochondrion | IBA | cellular_component |
| GO:0006259 | DNA metabolic process | TAS | biological_process |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0006273 | Lagging strand elongation | IBA | biological_process |
| GO:0006281 | DNA repair | IEA TAS | biological_process |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | TAS | biological_process |
| GO:0006284 | Base-excision repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | IBA TAS | biological_process |
| GO:0006297 | Nucleotide-excision repair, DNA gap filling | TAS | biological_process |
| GO:0006302 | Double-strand break repair | TAS | biological_process |
| GO:0006303 | Double-strand break repair via nonhomologous end joining | IEA | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0032201 | Telomere maintenance via semi-conservative replication | TAS | biological_process |
| GO:0033151 | V(D)J recombination | IDA | biological_process |
| GO:0042542 | Response to hydrogen peroxide | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051103 | DNA ligation involved in DNA repair | IEA | biological_process |
| GO:0051301 | Cell division | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9196282474 | 0.0110770981 | 0.9999902473 | 0.2083282965 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0849497824 |
| GSE13712_SHEAR | Up | 0.4718671295 |
| GSE13712_STATIC | Down | -0.0340855907 |
| GSE19018 | Up | 0.0458786334 |
| GSE19899_A1 | Down | -0.4588029524 |
| GSE19899_A2 | Down | -2.1234077078 |
| PubMed_21979375_A1 | Down | -0.6602744835 |
| PubMed_21979375_A2 | Down | -0.9677771919 |
| GSE35957 | Down | -0.9926815764 |
| GSE36640 | Down | -1.2770201507 |
| GSE54402 | Down | -0.3618018172 |
| GSE9593 | Down | -1.0879696133 |
| GSE43922 | Down | -0.0339404784 |
| GSE24585 | Up | 0.0764861697 |
| GSE37065 | Down | -0.1772149883 |
| GSE28863_A1 | Down | -0.0353488970 |
| GSE28863_A2 | Up | 0.0524723409 |
| GSE28863_A3 | Up | 0.3785063589 |
| GSE28863_A4 | Up | 0.2319557332 |
| GSE48662 | Down | -0.6474907862 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Bleomycin | DB00290 | APRD00453 | EXPT00718 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030288 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040334 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045653 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26151554 | 1G1 cells bear a mutation in replicative DNA ligase I (LigI) which results in low levels of replication-dependent DNA damage |
| 22952233 | Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair |
| 22952233 | Human DNA ligase I (hLigI) joins Okazaki fragments during DNA replication and completes excision repair via interactions with proliferating cell nuclear antigen and replication factor C (RFC) |
| 19223468 | Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repair |
| 19223468 | Human DNA ligase I (hLigI) participates in DNA replication and excision repair via an interaction with proliferating cell nuclear antigen (PCNA), a DNA sliding clamp |
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