HCSGD entry for LGALS1

1. General information

Official gene symbolLGALS1
Entrez ID3956
Gene full namelectin, galactoside-binding, soluble, 1
Other gene symbolsGAL1 GBP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001948Glycoprotein bindingIEAmolecular_function
GO:0002317Plasma cell differentiationIEAbiological_process
GO:0004871Signal transducer activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005622IntracellularIDAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0007165Signal transductionIMPbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010812Negative regulation of cell-substrate adhesionIEAbiological_process
GO:0010977Negative regulation of neuron projection developmentIEAbiological_process
GO:0016936Galactoside bindingIEAmolecular_function
GO:0030395Lactose bindingIEAmolecular_function
GO:0031012Extracellular matrixIDA ISScellular_component
GO:0031295T cell costimulationIEAbiological_process
GO:0033555Multicellular organismal response to stressIEAbiological_process
GO:0034120Positive regulation of erythrocyte aggregationIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043236Laminin bindingIEAmolecular_function
GO:0045445Myoblast differentiationIEAbiological_process
GO:0048678Response to axon injuryIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60515034760.14664584170.99999024730.7398629864

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1160592133
GSE13712_SHEARUp0.1915869850
GSE13712_STATICUp0.0879095082
GSE19018Up0.3949706961
GSE19899_A1Down-0.1930970630
GSE19899_A2Down-0.0985722258
PubMed_21979375_A1Up0.4013948175
PubMed_21979375_A2Down-0.1225544919
GSE35957Down-0.2133159120
GSE36640Down-0.1466082281
GSE54402Up0.0276472489
GSE9593Up0.1094827537
GSE43922Down-0.0146582840
GSE24585Up1.2408564682
GSE37065Down-0.3527261179
GSE28863_A1Down-0.3687580034
GSE28863_A2Down-0.3529831412
GSE28863_A3Down-0.2200927993
GSE28863_A4Up0.1417835791
GSE48662Down-0.6007065541

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL457430CHEMBL49158P09382
CHEMBL443156CHEMBL49158P09382
CHEMBL52011CHEMBL49158P09382
CHEMBL458489CHEMBL49158P09382
CHEMBL203050CHEMBL49158P09382
CHEMBL509180CHEMBL49158P09382
CHEMBL444662CHEMBL49158P09382
CHEMBL505576CHEMBL49158P09382
CHEMBL503116CHEMBL49158P09382
CHEMBL516152CHEMBL49158P09382
CHEMBL509915CHEMBL49158P09382
CHEMBL457221CHEMBL49158P09382
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  • Drugs

Name

Drug

Accession number

Beta-MercaptoethanolDB03345 EXPT02882 | DB03131
ThiodigalactosideDB04396 EXPT03030
1,4-DithiothreitolDB04447 EXPT01291

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023570ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23969227Stringent reduction of the extensive proteomic data from this tumor cell model revealed a list of 59 markers including proteins identified in our former studies and a number of novel proteins involved in tumorigenesis and metastasis such as SFN, S100A4, ANXA2, and LGALS1
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