HCSGD entry for LDLR
1. General information
| Official gene symbol | LDLR |
|---|---|
| Entrez ID | 3949 |
| Gene full name | low density lipoprotein receptor |
| Other gene symbols | FH FHC LDLCQ2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001523 | Retinoid metabolic process | TAS | biological_process |
| GO:0001948 | Glycoprotein binding | IPI | molecular_function |
| GO:0005041 | Low-density lipoprotein receptor activity | IDA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005764 | Lysosome | IDA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005770 | Late endosome | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0005905 | Coated pit | IDA | cellular_component |
| GO:0006629 | Lipid metabolic process | TAS | biological_process |
| GO:0006897 | Endocytosis | TAS | biological_process |
| GO:0006898 | Receptor-mediated endocytosis | TAS | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0009897 | External side of plasma membrane | IDA | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010008 | Endosome membrane | TAS | cellular_component |
| GO:0010867 | Positive regulation of triglyceride biosynthetic process | ISS | biological_process |
| GO:0010899 | Regulation of phosphatidylcholine catabolic process | ISS | biological_process |
| GO:0015914 | Phospholipid transport | ISS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0030169 | Low-density lipoprotein particle binding | IEA | molecular_function |
| GO:0030229 | Very-low-density lipoprotein particle receptor activity | IDA | molecular_function |
| GO:0030299 | Intestinal cholesterol absorption | IMP | biological_process |
| GO:0030301 | Cholesterol transport | IMP | biological_process |
| GO:0030669 | Clathrin-coated endocytic vesicle membrane | TAS | cellular_component |
| GO:0034362 | Low-density lipoprotein particle | IEA | cellular_component |
| GO:0034383 | Low-density lipoprotein particle clearance | IMP | biological_process |
| GO:0042157 | Lipoprotein metabolic process | TAS | biological_process |
| GO:0042159 | Lipoprotein catabolic process | IEA | biological_process |
| GO:0042632 | Cholesterol homeostasis | IMP | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0070508 | Cholesterol import | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0769254132 | 0.5368746058 | 0.5860199363 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3523497378 |
| GSE13712_SHEAR | Up | 0.5437236824 |
| GSE13712_STATIC | Down | -0.1302812229 |
| GSE19018 | Down | -0.1359843064 |
| GSE19899_A1 | Down | -0.0215884806 |
| GSE19899_A2 | Up | 0.4324615702 |
| PubMed_21979375_A1 | Down | -0.3196984217 |
| PubMed_21979375_A2 | Up | 0.0016340753 |
| GSE35957 | Down | -0.0608160534 |
| GSE36640 | Up | 0.5078998922 |
| GSE54402 | Up | 0.1997191287 |
| GSE9593 | Up | 0.4277437533 |
| GSE43922 | Down | -0.2343463278 |
| GSE24585 | Down | -0.1801480083 |
| GSE37065 | Up | 0.1894824006 |
| GSE28863_A1 | Up | 0.6118159397 |
| GSE28863_A2 | Up | 0.6547980910 |
| GSE28863_A3 | Down | -0.0613139071 |
| GSE28863_A4 | Up | 0.0032476739 |
| GSE48662 | Down | -0.6402730215 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Porfimer | DB00707 | APRD00078 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130a-3p | MIMAT0000425 | MIRT007140 | qRT-PCR | Functional MTI (Weak) | 23418453 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017122 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020235 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021895 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022254 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT027940 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028459 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031195 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032197 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037702 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26b-3p | MIMAT0004500 | MIRT038952 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040715 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045415 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049680 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26112889 | Most of these data were derived from experimental findings in genetically modified mice, where NFkappaB, Pcsk9, low-density lipoprotein-receptor, PPARgamma, superoxide dismutase 2, poly[adenosine diphosphate-ribose] polymerase 1, and endothelial nitric oxide synthase were identified among others as crucial molecular targets and/or partners of sirtuins |
| 24651677 | APPROACH AND RESULTS: LDLR(-/-) (low-density lipoprotein receptor(-/-)) mice were exposed to a high-fat diet for 2 to 12 weeks (or to a normal chow diet as a control) before the assessment of cellular senescence in aortic ECs |
| 22052190 | Notably, PATZ1 immunoreactivity was lower in ECs of atherosclerotic tissues than those of normal arteries in LDLR(-/-) mice, and immunoreactivity also decreased in ECs of old human arteries |
| 6519666 | Effect of clonal senescence on low density lipoprotein-receptor activity of bovine arterial endothelial cells |
| 6519666 | Senescent and young bovine arterial endothelial cells derived from the same parental cell clone were compared to test the effect of in vitro endothelial cell senescence on low density lipoprotein (LDL) and modified LDL-receptor activities |
| 6519666 | The increased LDL-receptor activity associated with endothelial cell senescence remained significant after variation of cell number among senescent and young clones was taken into account |
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