HCSGD entry for LBR
1. General information
| Official gene symbol | LBR |
|---|---|
| Entrez ID | 3930 |
| Gene full name | lamin B receptor |
| Other gene symbols | DHCR14B LMN2R PHA TDRD18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005521 | Lamin binding | TAS | molecular_function |
| GO:0005635 | Nuclear envelope | IEA TAS | cellular_component |
| GO:0005639 | Integral component of nuclear inner membrane | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IDA | cellular_component |
| GO:0016628 | Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | IEA | molecular_function |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0070087 | Chromo shadow domain binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9836417499 | 0.0001214278 | 0.9999902473 | 0.0197282209 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.4058248704 |
| GSE13712_SHEAR | Down | -0.4025447357 |
| GSE13712_STATIC | Down | -0.2367946754 |
| GSE19018 | Down | -0.4350616074 |
| GSE19899_A1 | Down | -1.8078418461 |
| GSE19899_A2 | Down | -2.1369269705 |
| PubMed_21979375_A1 | Down | -1.1403822088 |
| PubMed_21979375_A2 | Down | -2.4354336169 |
| GSE35957 | Down | -2.6135642660 |
| GSE36640 | Down | -2.1087217559 |
| GSE54402 | Down | -0.6861630783 |
| GSE9593 | Down | -1.5397533402 |
| GSE43922 | Down | -0.4775543826 |
| GSE24585 | Down | -0.1423755671 |
| GSE37065 | Down | -0.1296118733 |
| GSE28863_A1 | Up | 0.8379906432 |
| GSE28863_A2 | Up | 1.1958020631 |
| GSE28863_A3 | Down | -0.6942349369 |
| GSE28863_A4 | Down | -0.1089314104 |
| GSE48662 | Down | -0.8449442490 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-340-5p | MIMAT0004692 | MIRT019632 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020277 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021190 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022092 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025202 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-148a-3p | MIMAT0000243 | MIRT026004 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026051 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027366 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028716 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030542 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031247 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032162 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032443 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-421 | MIMAT0003339 | MIRT039426 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041836 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046348 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT047214 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27059139 | Aberrant localization of lamin B receptor (LBR) in cellular senescence in human cells |
| 27059139 | We have shown here that lamin B receptor (LBR) showed a change in localization in both BrdU-induced and replicative senescent cells |
| 22993662 | The immunosuppressive properties of PLC-MSC on resting and phytohemagglutinin (PHA) stimulated allogenic T cells were assessed by means of cell proliferation via incorporation of tritium thymidine ((3)H-TdR) |
| 22993662 | In terms of their immunosuppressive properties, PLC-MSC were unable to stimulate resting T cell proliferation; they inhibited the PHA stimulated T cells in a dose dependent manner through cell to cell contact |
| 16313945 | PBMCs were stimulated with phytohemagglutinin (PHA) (10 microg/ml) |
| 11554612 | Fresh NAMNC, non-stimulated or activated in vitro with PHA or with a mixture of monoclonal antibodies against CD3 and against CD28 membrane antigens (in order to obtain prevalent T cell responses), were exposed to Saquinavir before or at the time of mitogenic stimulation |
| 11554612 | The results indicate that Saquinavir is able to increase proliferation and interferon-gamma release in PHA-stimulated NAMNC, and telomerase activity either in non-stimulated and in PHA or antibody-activated cells |
| 9704925 | We show that PHA and IL-2 stimulated T-lymphocytes cease to proliferate after around 20 population doublings, these cells can not thereafter be restimulated to growth, and were also found to exhibit markers for senescence |
| 8582660 | The results show that AL rats exhibit an age-related decrease in proliferative response of splenic lymphocytes to phytohemagglutinin (PHA) and concanavalin A (Con A) |
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