HCSGD entry for GDF6
1. General information
| Official gene symbol | GDF6 |
|---|---|
| Entrez ID | 392255 |
| Gene full name | growth differentiation factor 6 |
| Other gene symbols | BMP13 CDMP2 KFM KFS KFS1 KFSL MCOP4 MCOPCB6 SCDO4 SGM1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006915 | Apoptotic process | ISS | biological_process |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0010862 | Positive regulation of pathway-restricted SMAD protein phosphorylation | IDA | biological_process |
| GO:0030509 | BMP signaling pathway | IDA | biological_process |
| GO:0032924 | Activin receptor signaling pathway | IDA | biological_process |
| GO:0040007 | Growth | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0045666 | Positive regulation of neuron differentiation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0060389 | Pathway-restricted SMAD protein phosphorylation | IDA | biological_process |
| GO:1990009 | Retinal cell apoptotic process | ISS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0407040652 | 0.9840685916 | 0.4523692081 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | Down | -0.5447460754 |
| GSE24585 | Up | 0.1356388381 |
| GSE37065 | Up | 0.4382219521 |
| GSE28863_A1 | Up | 0.1793461668 |
| GSE28863_A2 | Up | 0.1807962393 |
| GSE28863_A3 | Up | 0.3559532493 |
| GSE28863_A4 | Up | 0.2513953705 |
| GSE48662 | Up | 0.4575438801 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27311402 | Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues |
| 27311402 | In this study, we identified growth differentiation factor 6 (Gdf6; also known as Bmp13 and CDMP-2) as a regenerative factor secreted from young MSCs |
| 27311402 | The expression of specific secretory factors, including Gdf6, was regulated by the microRNA (miRNA) miR-17, whose expression declined with age |
| 27311402 | Upregulation of Gdf6 restored the osteogenic capacity of old MSCs in vitro and exerted positive effects in vivo on aging-associated pathologies such as reduced lymphopoiesis, insufficient muscle repair, reduced numbers of neural progenitors in the brain, and chronic inflammation |
Entries Per Page
Displaying Page of
