HCSGD entry for ARHGAP1
1. General information
| Official gene symbol | ARHGAP1 |
|---|---|
| Entrez ID | 392 |
| Gene full name | Rho GTPase activating protein 1 |
| Other gene symbols | CDC42GAP RHOGAP RHOGAP1 p50rhoGAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001726 | Ruffle | IEA | cellular_component |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005100 | Rho GTPase activator activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IDA TAS | biological_process |
| GO:0007266 | Rho protein signal transduction | TAS | biological_process |
| GO:0009967 | Positive regulation of signal transduction | TAS | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0030675 | Rac GTPase activator activity | IEA | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5346987652 | 0.5116887770 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0491512194 |
| GSE13712_SHEAR | Up | 0.0570160270 |
| GSE13712_STATIC | Up | 0.0650390930 |
| GSE19018 | Down | -0.0322786635 |
| GSE19899_A1 | Down | -0.1798026391 |
| GSE19899_A2 | Up | 0.0637397687 |
| PubMed_21979375_A1 | Down | -0.2583988807 |
| PubMed_21979375_A2 | Down | -0.2195053309 |
| GSE35957 | Up | 0.4661688182 |
| GSE36640 | Down | -0.0054881517 |
| GSE54402 | Down | -0.1138995495 |
| GSE9593 | Up | 0.1441892431 |
| GSE43922 | Down | -0.2388471236 |
| GSE24585 | Up | 0.2856260421 |
| GSE37065 | Down | -0.1770968455 |
| GSE28863_A1 | Up | 0.4886022671 |
| GSE28863_A2 | Up | 0.3222836371 |
| GSE28863_A3 | Down | -0.1008806653 |
| GSE28863_A4 | Up | 0.0098852924 |
| GSE48662 | Down | -0.1174060418 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020316 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025280 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025280 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028087 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031242 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17227869 | Cdc42GAP-/- mouse embryonic fibroblasts and/or tissues display reduced population doubling, significantly dampened DNA damage repair activity after DNA-damaging agent treatment, accumulated genomic abnormalities, and induction of p53, p16Ink4a, p21Cip1, and senescence-associated beta-galactosidase expressions |
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