HCSGD entry for LAG3
1. General information
| Official gene symbol | LAG3 |
|---|---|
| Entrez ID | 3902 |
| Gene full name | lymphocyte-activation gene 3 |
| Other gene symbols | CD223 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003823 | Antigen binding | TAS | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | IEA | molecular_function |
| GO:0007166 | Cell surface receptor signaling pathway | IEA | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0042289 | MHC class II protein binding | IDA | molecular_function |
| GO:0045085 | Negative regulation of interleukin-2 biosynthetic process | IEA | biological_process |
| GO:0045954 | Positive regulation of natural killer cell mediated cytotoxicity | IEA | biological_process |
| GO:0050868 | Negative regulation of T cell activation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3721065917 | 0.7703382774 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0658236609 |
| GSE13712_SHEAR | Down | -0.1387031339 |
| GSE13712_STATIC | Up | 0.0850282887 |
| GSE19018 | Up | 0.0967100719 |
| GSE19899_A1 | Down | -0.0291653347 |
| GSE19899_A2 | Up | 0.3425410194 |
| PubMed_21979375_A1 | Up | 0.1811270594 |
| PubMed_21979375_A2 | Down | -0.1087905315 |
| GSE35957 | Up | 0.0350675060 |
| GSE36640 | Up | 0.0676878661 |
| GSE54402 | Down | -0.0016630456 |
| GSE9593 | Down | -0.0567869255 |
| GSE43922 | Up | 0.2130059850 |
| GSE24585 | Up | 0.0647265657 |
| GSE37065 | Down | -0.0010957048 |
| GSE28863_A1 | Down | -0.1136195574 |
| GSE28863_A2 | Down | -0.1719591096 |
| GSE28863_A3 | Up | 0.5379443284 |
| GSE28863_A4 | Up | 0.1939516765 |
| GSE48662 | Down | -0.2298799611 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
