HCSGD entry for LIN28B
1. General information
| Official gene symbol | LIN28B |
|---|---|
| Entrez ID | 389421 |
| Gene full name | lin-28 homolog B (C. elegans) |
| Other gene symbols | CSDD2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010587 | MiRNA catabolic process | IMP | biological_process |
| GO:0031054 | Pre-miRNA processing | IMP | biological_process |
| GO:0031123 | RNA 3'-end processing | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6510315110 | 0.7074383686 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0792608935 |
| GSE13712_SHEAR | Up | 0.0158987031 |
| GSE13712_STATIC | Up | 0.2187739638 |
| GSE19018 | Up | 0.1528642461 |
| GSE19899_A1 | Up | 0.1135143123 |
| GSE19899_A2 | Down | -0.0244829611 |
| PubMed_21979375_A1 | Down | -0.0358250009 |
| PubMed_21979375_A2 | Down | -0.0437041027 |
| GSE35957 | Down | -0.0086619167 |
| GSE36640 | Up | 0.1736872594 |
| GSE54402 | Up | 0.1437981961 |
| GSE9593 | Up | 0.0502545674 |
| GSE43922 | Up | 0.0155601929 |
| GSE24585 | Down | -0.4458278886 |
| GSE37065 | Up | 0.0137296212 |
| GSE28863_A1 | Up | 0.0854997777 |
| GSE28863_A2 | Down | -0.0452681513 |
| GSE28863_A3 | Up | 0.2082513375 |
| GSE28863_A4 | Up | 0.0346120647 |
| GSE48662 | Down | -0.0815878613 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT003834 | Microarray | Functional MTI (Weak) | 17699775 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT003834 | Luciferase reporter assay | Functional MTI | 16971064 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT005804 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20827722 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT019513 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026096 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032185 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-484 | MIMAT0002174 | MIRT042267 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045709 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046425 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048544 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25931205 | More recent global analysis of mRNA and microRNA expression comparing these two types of pro-B cells revealed differential expression of Lin28b and microRNAs from the Let-7 family, indicating that this regulatory axis plays a role in the switch |
| 20512147 | Recently, genome-wide association studies have implicated the human LIN28B locus in regulating height and the timing of menarche |
| 20512147 | LIN28B and its homolog LIN28A are functionally redundant RNA-binding proteins that block biogenesis of let-7 microRNAs |
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