HCSGD entry for KRT19
1. General information
| Official gene symbol | KRT19 |
|---|---|
| Entrez ID | 3880 |
| Gene full name | keratin 19 |
| Other gene symbols | CK19 K19 K1CS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005882 | Intermediate filament | IEA | cellular_component |
| GO:0008307 | Structural constituent of muscle | IDA | molecular_function |
| GO:0016010 | Dystrophin-associated glycoprotein complex | IEA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0042383 | Sarcolemma | IEA | cellular_component |
| GO:0043034 | Costamere | IDA | cellular_component |
| GO:0043627 | Response to estrogen | IEP | biological_process |
| GO:0045214 | Sarcomere organization | IDA | biological_process |
| GO:0060706 | Cell differentiation involved in embryonic placenta development | IEA | biological_process |
| GO:0071944 | Cell periphery | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1364215835 | 0.0310203450 | 0.7450168637 | 0.3311875101 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2476688524 |
| GSE13712_SHEAR | Up | 1.0152324489 |
| GSE13712_STATIC | Up | 1.6843885189 |
| GSE19018 | Down | -0.0691992656 |
| GSE19899_A1 | Up | 0.0201535985 |
| GSE19899_A2 | Down | -0.1706080975 |
| PubMed_21979375_A1 | Down | -0.2386135625 |
| PubMed_21979375_A2 | Down | -1.1338893016 |
| GSE35957 | Up | 0.5843669922 |
| GSE36640 | Down | -0.4495804671 |
| GSE54402 | Down | -1.0533750996 |
| GSE9593 | Up | 0.0145984946 |
| GSE43922 | Down | -0.2846183185 |
| GSE24585 | Down | -0.0262585033 |
| GSE37065 | Down | -0.3215663859 |
| GSE28863_A1 | Down | -0.4588792894 |
| GSE28863_A2 | Up | 0.1331594587 |
| GSE28863_A3 | Down | -0.0594099025 |
| GSE28863_A4 | Up | 0.1973288713 |
| GSE48662 | Down | -0.9435280739 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016304 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016860 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24796186 | At 14 days after culture, frozen sections were prepared and were stained with HE to observe the cells morphology, and immunohistochemical analysis was used to detect the antigen expressions of cytokeratin 7 (CK7) and CK19 |
| 24796186 | Immunohistochemical analysis showed that CK7 and CK19 antigens expressed positively in the cells |
| 21486894 | RESULTS: Bile ductules positive for CK19 were increased along with the progression of staging and fibrosis of NAFLD, and the increased bile ductules were associated with portal inflammation and fibrosis |
| 21486894 | Small spindle-like cells positive for CK7 alone in the hepatic parenchyma in the advanced stage seem to differentiate to periportal bile ductular cells positive for CK19 and CK7 |
| 15265523 | A previous study on K19 found that the loss of stem cell proportion is the reason for difficulties experienced when culturing aged keratinocytes |
| 15265523 | But the situation is unclear, because K19 is not generally accepted as an epidermal stem cell marker |
| 8018955 | SUM-16LN cells were keratin-19 positive and had an aneuploid karyotype |
| 1692339 | A wide range of keratins were expressed by the tumour xenografts; cornified keratins (K1, K10) were only expressed in the absence of K19 and vimentin, and vice versa |
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