HCSGD entry for SETD8
1. General information
| Official gene symbol | SETD8 |
|---|---|
| Entrez ID | 387893 |
| Gene full name | SET domain containing (lysine methyltransferase) 8 |
| Other gene symbols | KMT5A PR-Set7 SET07 SET8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0002039 | P53 binding | IPI | molecular_function |
| GO:0003714 | Transcription corepressor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0016279 | Protein-lysine N-methyltransferase activity | IDA | molecular_function |
| GO:0016571 | Histone methylation | IDA | biological_process |
| GO:0018024 | Histone-lysine N-methyltransferase activity | IDA IEA | molecular_function |
| GO:0018026 | Peptidyl-lysine monomethylation | IDA | biological_process |
| GO:0034968 | Histone lysine methylation | IDA | biological_process |
| GO:0043516 | Regulation of DNA damage response, signal transduction by p53 class mediator | IMP | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9583525132 | 0.0946441625 | 0.9999902473 | 0.5862859496 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0872185634 |
| GSE13712_SHEAR | Up | 0.0921623917 |
| GSE13712_STATIC | Down | -0.1904307256 |
| GSE19018 | Down | -0.5463562461 |
| GSE19899_A1 | Down | -0.2853144628 |
| GSE19899_A2 | Down | -0.0534156866 |
| PubMed_21979375_A1 | Down | -0.0150473091 |
| PubMed_21979375_A2 | Down | -0.6079194925 |
| GSE35957 | Down | -0.5056733294 |
| GSE36640 | Down | -0.3119609501 |
| GSE54402 | Up | 0.0392421216 |
| GSE9593 | Up | 0.0534862328 |
| GSE43922 | Up | 0.0668248950 |
| GSE24585 | Down | -0.1519380229 |
| GSE37065 | Down | -0.2049552125 |
| GSE28863_A1 | Up | 0.0871401976 |
| GSE28863_A2 | Down | -0.1967374684 |
| GSE28863_A3 | Up | 0.0389263558 |
| GSE28863_A4 | Up | 0.0985608631 |
| GSE48662 | Up | 0.0174858105 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-127-3p | MIMAT0000446 | MIRT006953 | Luciferase reporter assay | Functional MTI | 22720056 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016360 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-375 | MIMAT0000728 | MIRT019883 | qRT-PCR;Microarray | Functional MTI (Weak) | 20584986 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025791 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045160 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-502-5p | MIMAT0002873 | 1 | hsa-miR-502-5p | 19789321 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
