HCSGD entry for KRT10
1. General information
| Official gene symbol | KRT10 |
|---|---|
| Entrez ID | 3858 |
| Gene full name | keratin 10 |
| Other gene symbols | BCIE BIE CK10 EHK K10 KPP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005882 | Intermediate filament | NAS | cellular_component |
| GO:0030216 | Keratinocyte differentiation | IEP | biological_process |
| GO:0030280 | Structural constituent of epidermis | NAS | molecular_function |
| GO:0045095 | Keratin filament | IEA | cellular_component |
| GO:0071277 | Cellular response to calcium ion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8988899434 | 0.4201124349 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0924262000 |
| GSE13712_SHEAR | Down | -0.0508905434 |
| GSE13712_STATIC | Down | -0.1281166269 |
| GSE19018 | Up | 0.1248354981 |
| GSE19899_A1 | Down | -0.2101555739 |
| GSE19899_A2 | Up | 0.0159940330 |
| PubMed_21979375_A1 | Down | -0.6404994502 |
| PubMed_21979375_A2 | Down | -0.0765705872 |
| GSE35957 | Down | -0.1798543673 |
| GSE36640 | Down | -0.2034187697 |
| GSE54402 | Up | 0.0651146701 |
| GSE9593 | Down | -0.1783434446 |
| GSE43922 | Up | 0.0555494645 |
| GSE24585 | Up | 0.0626276412 |
| GSE37065 | Down | -0.1099108993 |
| GSE28863_A1 | Down | -0.0607443561 |
| GSE28863_A2 | Down | -0.0195139450 |
| GSE28863_A3 | Up | 0.0693860258 |
| GSE28863_A4 | Up | 0.1277313228 |
| GSE48662 | Down | -0.0453340823 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023292 | Proteomics | Functional MTI (Weak) | 21750653 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23504375 | In equivalents generated with late passage fibroblasts epidermal expression of keratin 6 was increased, and of keratin 10 slightly decreased |
| 22981852 | Previously we have demonstrated that cellular senescence enhances permissiveness for bacterial pneumonia through increased expression of the bacterial ligands Laminin receptor (LR), Platelet-activating factor receptor (PAFr) and Cytokeratin 10 (K10) |
| 22981852 | Mice on eRapa also had marked reductions in PAFr, LR, and K10 |
| 21615674 | Keratin 10 (K10), laminin receptor (LR), and platelet-activating factor receptor (PAFr), host proteins known to be co-opted for bacterial adhesion, were also increased |
| 21615674 | Aged mice were found to be highly susceptible to pneumococcal challenge in a PsrP, the pneumococcal adhesin that binds K10, dependent manner |
| 21615674 | In vitro senescent A549 lung epithelial cells had elevated K10 and LR protein levels and were up to 5-fold more permissive for bacterial adhesion |
| 8168156 | The senescent cells occasionally had keratohyaline granules in the cytoplasm and were positive in immunohistochemistry for keratinizing squamous epithelium-specific cytokeratin 10 |
| 1692339 | A wide range of keratins were expressed by the tumour xenografts; cornified keratins (K1, K10) were only expressed in the absence of K19 and vimentin, and vice versa |
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