HCSGD entry for KRT7
1. General information
| Official gene symbol | KRT7 |
|---|---|
| Entrez ID | 3855 |
| Gene full name | keratin 7 |
| Other gene symbols | CK7 K2C7 K7 SCL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005882 | Intermediate filament | NAS | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0045095 | Keratin filament | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2612513354 | 0.0346615440 | 0.9545247640 | 0.3527386898 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6252329173 |
| GSE13712_SHEAR | Up | 0.6547374202 |
| GSE13712_STATIC | Up | 0.7395934045 |
| GSE19018 | Up | 0.0190819690 |
| GSE19899_A1 | Down | -0.0425378796 |
| GSE19899_A2 | Down | -0.0661996534 |
| PubMed_21979375_A1 | Down | -0.0699105006 |
| PubMed_21979375_A2 | Up | 0.0252119661 |
| GSE35957 | Up | 0.0902393168 |
| GSE36640 | Down | -0.2922478010 |
| GSE54402 | Down | -0.5227407527 |
| GSE9593 | Down | -0.4374705884 |
| GSE43922 | Up | 0.0445308521 |
| GSE24585 | Down | -0.0684911982 |
| GSE37065 | Down | -0.7017502149 |
| GSE28863_A1 | Down | -0.5254824714 |
| GSE28863_A2 | Down | -0.8452023572 |
| GSE28863_A3 | Up | 1.2101424723 |
| GSE28863_A4 | Up | 0.1414763540 |
| GSE48662 | Down | -0.1059545834 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-133a-3p | MIMAT0000427 | MIRT000331 | Immunoblot//qRT-PCR | Functional MTI (Weak) | 19378336 |
| hsa-miR-199a-3p | MIMAT0000232 | MIRT003324 | Immunoblot//qRT-PCR | Functional MTI (Weak) | 19378336 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT004936 | Immunoblot//qRT-PCR | Non-Functional MTI (Weak) | 19378336 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT004937 | Immunoblot//qRT-PCR | Non-Functional MTI (Weak) | 19378336 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT004938 | Immunoblot//qRT-PCR | Non-Functional MTI (Weak) | 19378336 |
| hsa-miR-30a-3p | MIMAT0000088 | MIRT004939 | Immunoblot//qRT-PCR | Functional MTI (Weak) | 19378336 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025743 | Microarray | Functional MTI (Weak) | 19073608 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-145-5p | MIMAT0000437 | NA | hsa-miR-145 | {Western blot} | {overexpression by miRNA precursor transfection} | 19378336 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27177832 | Restricted tumor growth was associated with marginally increased tumor cell senescence and cellular differentiation, showed with senescence-associated-beta-galactosidase and cytokeratin 7 staining |
| 26640786 | RESULTS: Comparison of protein pattern of senescent and young HPMC revealed 29 differentially abundant protein spots, 11 of which were identified to be actin (cytoplasmic 1 and 2), cytokeratin-7, cofilin-2, transgelin-2, Hsp60, Hsc70, proteasome beta-subunits (type-2 and type-3), nucleoside diphosphate kinase A, and cytosolic 5'(3')-deoxyribonucleotidase |
| 25046437 | Isolated PSC cells expressed cholangiocyte (eg, cytokeratin 7 and 19) and epithelial cell adhesion markers (EPCAM, ICAM) and were negative for hepatocyte and myofibroblast markers (albumin, alpha-actin) |
| 24796186 | At 14 days after culture, frozen sections were prepared and were stained with HE to observe the cells morphology, and immunohistochemical analysis was used to detect the antigen expressions of cytokeratin 7 (CK7) and CK19 |
| 24796186 | Immunohistochemical analysis showed that CK7 and CK19 antigens expressed positively in the cells |
| 21486894 | Small spindle-like cells positive for CK7 alone in the hepatic parenchyma in the advanced stage seem to differentiate to periportal bile ductular cells positive for CK19 and CK7 |
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