HCSGD entry for KRT5
1. General information
| Official gene symbol | KRT5 |
|---|---|
| Entrez ID | 3852 |
| Gene full name | keratin 5 |
| Other gene symbols | CK5 DDD EBS2 K5 KRT5A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005882 | Intermediate filament | IDA IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0008544 | Epidermis development | TAS | biological_process |
| GO:0031581 | Hemidesmosome assembly | TAS | biological_process |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0045095 | Keratin filament | IDA IEA | cellular_component |
| GO:0097110 | Scaffold protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6562268949 | 0.5442865089 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1356334784 |
| GSE13712_SHEAR | Up | 0.2088192198 |
| GSE13712_STATIC | Up | 0.1246583414 |
| GSE19018 | Up | 0.3763345436 |
| GSE19899_A1 | Down | -0.0754101070 |
| GSE19899_A2 | Down | -0.1132848763 |
| PubMed_21979375_A1 | Up | 0.0019957727 |
| PubMed_21979375_A2 | Down | -0.0367337955 |
| GSE35957 | Up | 0.1828462773 |
| GSE36640 | Down | -0.0538526666 |
| GSE54402 | Down | -0.0208382128 |
| GSE9593 | Up | 0.0150187665 |
| GSE43922 | Up | 0.0964555527 |
| GSE24585 | Up | 0.1454940212 |
| GSE37065 | Down | -0.1115767789 |
| GSE28863_A1 | Up | 0.0096084366 |
| GSE28863_A2 | Down | -0.3062184598 |
| GSE28863_A3 | Up | 0.2804192764 |
| GSE28863_A4 | Down | -0.1714404094 |
| GSE48662 | Down | -0.0270678027 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-196a-5p | MIMAT0000226 | MIRT000221 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19342367 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017843 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-196a-5p | MIMAT0000226 | 1 | hsa-miR-196a | 19342367 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26940203 | In this study, the cell senescence phenotype was found to be more prominent in the CEP cells obtained from disc degenerative disease (DDD) patients than in the CEP cells obtained from age-matched lumbar vertebral fractures (LVF) patients |
| 23983186 | Human degenerative disc disease (DDD) is characterized by progressive loss of human nucleus pulposus (HNP) cells and extracellular matrix, in which the massive deposition are secreted by HNP cells |
| 23983186 | Cell therapy to supplement HNP cells to degenerated discs has been thought to be a promising strategy to treat DDD |
| 23983186 | Our study suggests that lentiviral vector might be a useful gene delivery vehicle for HNP cell therapy to treat DDD |
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