HCSGD entry for IPO5


1. General information

Official gene symbolIPO5
Entrez ID3843
Gene full nameimportin 5
Other gene symbolsIMB3 KPNB3 Pse1 RANBP5 imp5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005095GTPase inhibitor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005643Nuclear poreTAScellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmISScellular_component
GO:0006607NLS-bearing protein import into nucleusIEA ISSbiological_process
GO:0006610Ribosomal protein import into nucleusIDAbiological_process
GO:0006886Intracellular protein transportIEAbiological_process
GO:0008536Ran GTPase bindingIEAmolecular_function
GO:0008565Protein transporter activityIEA ISSmolecular_function
GO:0016032Viral processIEAbiological_process
GO:0042307Positive regulation of protein import into nucleusISSbiological_process
GO:0043086Negative regulation of catalytic activityTASbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
GO:0071230Cellular response to amino acid stimulusISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18024784770.20801012120.83218796700.8832194973

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1573931866
GSE13712_SHEARDown-0.2769562290
GSE13712_STATICDown-0.1832223316
GSE19018Up0.0091967966
GSE19899_A1Down-0.2634164380
GSE19899_A2Down-0.1320431006
PubMed_21979375_A1Up0.3787699307
PubMed_21979375_A2Down-0.0518132257
GSE35957Up0.2798142975
GSE36640Down-0.6423127058
GSE54402Up0.2095651700
GSE9593Down-0.0108914126
GSE43922Down-0.0102816076
GSE24585Down-0.3813247307
GSE37065Down-0.3869783547
GSE28863_A1Up1.2735107125
GSE28863_A2Up0.8683195049
GSE28863_A3Up0.5946964254
GSE28863_A4Up0.0102298947
GSE48662Down-0.3170255232

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1296-5pMIMAT0005794MIRT036092CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036844CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041786CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043188CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046603CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048251CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048827CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049490CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051154CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15034937Using bioinformatics-, Western-blotting-, yeast-two-hybrid-system-, polymerase chain reaction (PCR)-, and fluorescence microscopy-analyses, we demonstrate here that the neuroprotective protein p60TRP (p60-transcription-regulator-protein) is a basic helix-loop-helix (bHLH) domain-containing member of a new protein family that interacts with the Ran-binding-protein-5 (RanBP5) and the protein-phosphatase-2A (PP2A)
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