HCSGD entry for KPNA3
1. General information
| Official gene symbol | KPNA3 |
|---|---|
| Entrez ID | 3839 |
| Gene full name | karyopherin alpha 3 (importin alpha 4) |
| Other gene symbols | IPOA4 SRP1 SRP1gamma SRP4 hSRP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005643 | Nuclear pore | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006461 | Protein complex assembly | TAS | biological_process |
| GO:0006607 | NLS-bearing protein import into nucleus | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IEA | molecular_function |
| GO:0008139 | Nuclear localization sequence binding | TAS | molecular_function |
| GO:0008565 | Protein transporter activity | IEA | molecular_function |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0046718 | Viral entry into host cell | IEA | biological_process |
| GO:0075732 | Viral penetration into host nucleus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9412237377 | 0.0861238289 | 0.9999902473 | 0.5575172897 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0964868216 |
| GSE13712_SHEAR | Up | 0.0264645088 |
| GSE13712_STATIC | Down | -0.0657223747 |
| GSE19018 | Up | 0.2198572960 |
| GSE19899_A1 | Down | -0.4506693020 |
| GSE19899_A2 | Down | -0.4618134019 |
| PubMed_21979375_A1 | Down | -0.1481026353 |
| PubMed_21979375_A2 | Up | 0.0189672311 |
| GSE35957 | Down | -0.2604654703 |
| GSE36640 | Up | 0.0600130165 |
| GSE54402 | Down | -0.0771156439 |
| GSE9593 | Up | 0.1932784573 |
| GSE43922 | Down | -0.2362994673 |
| GSE24585 | Down | -0.3901335544 |
| GSE37065 | Down | -0.1080362182 |
| GSE28863_A1 | Down | -0.1906838012 |
| GSE28863_A2 | Up | 0.1378922659 |
| GSE28863_A3 | Down | -0.7320291267 |
| GSE28863_A4 | Up | 0.1130011770 |
| GSE48662 | Down | -0.2180879593 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001447 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049397 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
