HCSGD entry for KPNB1
1. General information
| Official gene symbol | KPNB1 |
|---|---|
| Entrez ID | 3837 |
| Gene full name | karyopherin (importin) beta 1 |
| Other gene symbols | IMB1 IPO1 IPOB Impnb NTF97 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000060 | Protein import into nucleus, translocation | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005643 | Nuclear pore | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006309 | Apoptotic DNA fragmentation | TAS | biological_process |
| GO:0006606 | Protein import into nucleus | IDA | biological_process |
| GO:0006607 | NLS-bearing protein import into nucleus | TAS | biological_process |
| GO:0006610 | Ribosomal protein import into nucleus | IDA IEA | biological_process |
| GO:0006913 | Nucleocytoplasmic transport | IEA | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0008139 | Nuclear localization sequence binding | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | TAS | molecular_function |
| GO:0008536 | Ran GTPase binding | IEA | molecular_function |
| GO:0008565 | Protein transporter activity | IEA | molecular_function |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0019058 | Viral life cycle | TAS | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0075733 | Intracellular transport of virus | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9671741271 | 0.0305959842 | 0.9999902473 | 0.3301596311 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2952731416 |
| GSE13712_SHEAR | Down | -0.2536019220 |
| GSE13712_STATIC | Down | -0.1903891060 |
| GSE19018 | Up | 0.1004624510 |
| GSE19899_A1 | Down | -0.4780023702 |
| GSE19899_A2 | Down | -0.5622630876 |
| PubMed_21979375_A1 | Down | -0.7688324294 |
| PubMed_21979375_A2 | Down | -0.4647191112 |
| GSE35957 | Down | -0.1777026113 |
| GSE36640 | Down | -0.5961125551 |
| GSE54402 | Down | -0.1801564673 |
| GSE9593 | Up | 0.0936075348 |
| GSE43922 | Down | -0.1759413326 |
| GSE24585 | Down | -0.0626337428 |
| GSE37065 | Down | -0.2000762394 |
| GSE28863_A1 | Up | 0.1469856816 |
| GSE28863_A2 | Up | 0.5835490976 |
| GSE28863_A3 | Up | 0.1078547680 |
| GSE28863_A4 | Down | -0.1480546400 |
| GSE48662 | Down | -0.3023310502 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036147 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1236-3p | MIMAT0005591 | MIRT036250 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036355 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037153 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037560 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037877 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039019 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039764 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041827 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044704 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045512 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT045863 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046096 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046618 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047236 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT047765 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049219 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
