HCSGD entry for KIF11

1. General information

Official gene symbolKIF11
Entrez ID3832
Gene full namekinesin family member 11
Other gene symbolsEG5 HKSP KNSL1 MCLMR TRIP5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000922Spindle poleIDAcellular_component
GO:0003777Microtubule motor activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005819SpindleIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005871Kinesin complexIEAcellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0005876Spindle microtubuleIDAcellular_component
GO:0007018Microtubule-based movementTASbiological_process
GO:0007051Spindle organizationIMPbiological_process
GO:0007052Mitotic spindle organizationTASbiological_process
GO:0007067MitosisTASbiological_process
GO:0007100Mitotic centrosome separationIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0008152Metabolic processTASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0032403Protein complex bindingIDAmolecular_function
GO:0090307Spindle assembly involved in mitosisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.80910957410.00000646250.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.8776549350
GSE13712_SHEARDown-0.8693973294
GSE13712_STATICDown-0.6031210852
GSE19018Down-0.1793111459
GSE19899_A1Down-2.1251558962
GSE19899_A2Down-5.4695346421
PubMed_21979375_A1Down-3.4374550357
PubMed_21979375_A2Down-6.0783209056
GSE35957Down-4.8092681458
GSE36640Down-5.0539365883
GSE54402Down-1.6530148508
GSE9593Down-1.9130866916
GSE43922Down-2.9701287891
GSE24585Up0.2405131810
GSE37065Down-0.7293283001
GSE28863_A1Down-0.3580652206
GSE28863_A2Up1.5019911642
GSE28863_A3Down-0.5830412017
GSE28863_A4Up0.5723757449
GSE48662Down-1.8157371272

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]PhenolDB03996 EXPT01994
MonastrolDB04331 EXPT02296
(4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDEDB07064 -
N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDEDB08032 -
(5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDEDB08033 -
(2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamideDB08037 -
[(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONEDB08198 -
(2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDEDB08239 -
(1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINEDB08244 -
(2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDEDB08246 -
(5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDEDB08250 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016382MicroarrayFunctional MTI (Weak)20304954
hsa-miR-340-5pMIMAT0004692MIRT019584SequencingFunctional MTI (Weak)20371350
hsa-miR-186-5pMIMAT0000456MIRT021126SequencingFunctional MTI (Weak)20371350
hsa-miR-34a-5pMIMAT0000255MIRT025295ProteomicsFunctional MTI (Weak)21566225
hsa-miR-30a-5pMIMAT0000087MIRT028535ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.