HCSGD entry for ARG1

1. General information

Official gene symbolARG1
Entrez ID383
Gene full namearginase, liver
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000050Urea cycleIEA TASbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIEAbiological_process
GO:0004053Arginase activityEXPmolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006527Arginine catabolic processTASbiological_process
GO:0009635Response to herbicideIEAbiological_process
GO:0010042Response to manganese ionIEAbiological_process
GO:0010043Response to zinc ionIEAbiological_process
GO:0010269Response to selenium ionIEAbiological_process
GO:0010963Regulation of L-arginine importIEAbiological_process
GO:0014075Response to amineIEAbiological_process
GO:0030145Manganese ion bindingIEAmolecular_function
GO:0030324Lung developmentIEAbiological_process
GO:0032964Collagen biosynthetic processIEAbiological_process
GO:0033189Response to vitamin AIEAbiological_process
GO:0033197Response to vitamin EIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043200Response to amino acidIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046686Response to cadmium ionIEAbiological_process
GO:0048678Response to axon injuryIEAbiological_process
GO:0051597Response to methylmercuryIEAbiological_process
GO:0060056Mammary gland involutionIEAbiological_process
GO:0060135Maternal process involved in female pregnancyIEAbiological_process
GO:0070207Protein homotrimerizationIEAbiological_process
GO:0070301Cellular response to hydrogen peroxideIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071353Cellular response to interleukin-4IEAbiological_process
GO:0071377Cellular response to glucagon stimulusIEAbiological_process
GO:0071549Cellular response to dexamethasone stimulusIEAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89623280270.76543560650.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0142767563
GSE13712_SHEARDown-0.0872284811
GSE13712_STATICUp0.0282563150
GSE19018Down-0.0100027142
GSE19899_A1Up0.0611712571
GSE19899_A2Up0.0673118090
PubMed_21979375_A1Down-0.0562550619
PubMed_21979375_A2Up0.0427802905
GSE35957Up0.2039648690
GSE36640Down-0.0620431543
GSE54402Up0.0408729974
GSE9593Up0.0428722045
GSE43922Up0.0214071659
GSE24585Down-0.1254168957
GSE37065Down-0.0336964467
GSE28863_A1Down-0.0207431365
GSE28863_A2Down-0.0420173599
GSE28863_A3Up0.0785189892
GSE28863_A4Down-0.1435500462
GSE48662Up0.0311946076

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-OrnithineDB00129 NUTR00043
2(S)-Amino-6-Boronohexanoic AcidDB01983 EXPT00396
Nor-N-Omega-Hydroxy-L-ArginineDB02381 EXPT02371
Dinor-N(Omega)-Hydroxy-L-ArginineDB02499 EXPT01209
S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-CysteineDB02689 EXPT02875
N-Omega-Hydroxy-L-ArginineDB03144 EXPT01692
S-2-(Boronoethyl)-L-CysteineDB03731 EXPT02831
UreaDB03904 EXPT03203
Descarboxy-nor-N(Omega)-Hydroxy-L-ArginineDB04197 EXPT00467
S,S-(2-Hydroxyethyl)ThiocysteineDB04530 EXPT00954
DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACIDDB04585 -
S-propylamine-L-cysteineDB04648 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT024079ProteomicsFunctional MTI (Weak)18668040
hsa-miR-7-5pMIMAT0000252MIRT025899MicroarrayFunctional MTI (Weak)17612493
hsa-miR-30a-5pMIMAT0000087MIRT028633ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25902315In DM, arginase I activity was significantly higher in young RBC compared to HC but decreased during aging
25902315In HC, concentration of L-arginine, the substrate of RBC-NOS and arginase I, significantly dropped from young to old RBC
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