HCSGD entry for ACAT1

1. General information

Official gene symbolACAT1
Entrez ID38
Gene full nameacetyl-CoA acetyltransferase 1
Other gene symbolsACAT MAT T2 THIL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001889Liver developmentIEAbiological_process
GO:0003985Acetyl-CoA C-acetyltransferase activityEXP IEAmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneIEAcellular_component
GO:0005759Mitochondrial matrixIEA TAScellular_component
GO:0007420Brain developmentIEAbiological_process
GO:0009083Branched-chain amino acid catabolic processTASbiological_process
GO:0009725Response to hormoneIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0016747Transferase activity, transferring acyl groups other than amino-acyl groupsIEAmolecular_function
GO:0019899Enzyme bindingIEAmolecular_function
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042594Response to starvationIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046950Cellular ketone body metabolic processTASbiological_process
GO:0046951Ketone body biosynthetic processTASbiological_process
GO:0046952Ketone body catabolic processTASbiological_process
GO:0050662Coenzyme bindingIEAmolecular_function
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0060612Adipose tissue developmentIEAbiological_process
GO:0072229Metanephric proximal convoluted tubule developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90698711300.15904698150.99999024730.7701022075

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1118685671
GSE13712_SHEARDown-0.0118494902
GSE13712_STATICDown-0.0331185406
GSE19018Up0.0382778214
GSE19899_A1Down-0.2164151047
GSE19899_A2Down-0.1885817385
PubMed_21979375_A1Down-0.5811283055
PubMed_21979375_A2Down-0.1525720261
GSE35957Up0.0834001582
GSE36640Down-0.1955426662
GSE54402Down-0.1302238925
GSE9593Up0.0795213269
GSE43922Down-0.4687281765
GSE24585Down-0.3863222797
GSE37065Down-0.1288484896
GSE28863_A1Up0.3077081682
GSE28863_A2Up0.3678823519
GSE28863_A3Up0.0381597989
GSE28863_A4Up0.1246209924
GSE48662Down-0.4944865794

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-23b-3pMIMAT0000418MIRT023466SequencingFunctional MTI (Weak)20371350
hsa-miR-21-5pMIMAT0000076MIRT030744MicroarrayFunctional MTI (Weak)18591254
hsa-miR-1260bMIMAT0015041MIRT052670CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.