HCSGD entry for KIF2A
1. General information
| Official gene symbol | KIF2A |
|---|---|
| Entrez ID | 3796 |
| Gene full name | kinesin heavy chain member 2A |
| Other gene symbols | HK2 KIF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0003774 | Motor activity | TAS | molecular_function |
| GO:0003777 | Microtubule motor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005871 | Kinesin complex | IEA | cellular_component |
| GO:0005876 | Spindle microtubule | IDA | cellular_component |
| GO:0007018 | Microtubule-based movement | IEA TAS | biological_process |
| GO:0007052 | Mitotic spindle organization | IDA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007399 | Nervous system development | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008017 | Microtubule binding | IEA | molecular_function |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9075994795 | 0.0349508263 | 0.9999902473 | 0.3534241644 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3080766308 |
| GSE13712_SHEAR | Up | 0.0943809194 |
| GSE13712_STATIC | Down | -0.1566305022 |
| GSE19018 | Down | -0.4796890060 |
| GSE19899_A1 | Down | -0.4069549014 |
| GSE19899_A2 | Down | -0.5379766852 |
| PubMed_21979375_A1 | Up | 0.3543008327 |
| PubMed_21979375_A2 | Down | -0.5982077968 |
| GSE35957 | Down | -0.4399279455 |
| GSE36640 | Down | -0.7655999678 |
| GSE54402 | Up | 0.1014428134 |
| GSE9593 | Up | 0.0357712019 |
| GSE43922 | Down | -0.4327566879 |
| GSE24585 | Up | 0.0315074007 |
| GSE37065 | Up | 0.0175788024 |
| GSE28863_A1 | Up | 0.1051422117 |
| GSE28863_A2 | Up | 0.3490883793 |
| GSE28863_A3 | Down | -0.4441973422 |
| GSE28863_A4 | Down | -0.0611886829 |
| GSE48662 | Down | -0.7176690639 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT003853 | Luciferase reporter assay//Microarray | Functional MTI | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT003853 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT003853 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT004016 | Immunoblot//Immunocytochemistry//Luciferase reporter assay//qRT-PCR//Reporter assay;Other | Functional MTI | 19940135 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025350 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031888 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032432 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039652 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19940135 | To gain insight into the biological roles of miR-183 we investigated two potential novel targets: integrin beta1 (ITGB1) and kinesin 2alpha (KIF2A) |
| 19940135 | Targeting of the 3'-untranslated region (3'-UTR) of ITGB1 and KIF2A by miR-183 was confirmed by luciferase assay |
| 19940135 | Targeting of KIF2A by miR-183 resulted in some increase in the formation of cells with monopolar spindles in HeLa cells but not in human diploid fibroblast or human trabecular meshwork cells |
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