HCSGD entry for KCNQ2
1. General information
| Official gene symbol | KCNQ2 |
|---|---|
| Entrez ID | 3785 |
| Gene full name | potassium voltage-gated channel, KQT-like subfamily, member 2 |
| Other gene symbols | BFNC BFNS1 EBN EBN1 EIEE7 ENB1 HNSPC KCNA11 KV7.2 KVEBN1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005249 | Voltage-gated potassium channel activity | IEA TAS | molecular_function |
| GO:0005251 | Delayed rectifier potassium channel activity | IBA | molecular_function |
| GO:0005267 | Potassium channel activity | TAS | molecular_function |
| GO:0005886 | Plasma membrane | ISS TAS | cellular_component |
| GO:0006813 | Potassium ion transport | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008076 | Voltage-gated potassium channel complex | IEA | cellular_component |
| GO:0030506 | Ankyrin binding | IPI | molecular_function |
| GO:0033268 | Node of Ranvier | ISS | cellular_component |
| GO:0043194 | Axon initial segment | ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7959125945 | 0.8031199650 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0606319064 |
| GSE13712_SHEAR | Down | -0.0117081483 |
| GSE13712_STATIC | Down | -0.1012527083 |
| GSE19018 | Up | 0.0753673624 |
| GSE19899_A1 | Down | -0.0225069296 |
| GSE19899_A2 | Up | 0.0185815973 |
| PubMed_21979375_A1 | Down | -0.0568075767 |
| PubMed_21979375_A2 | Down | -0.2223075652 |
| GSE35957 | Down | -0.0064873318 |
| GSE36640 | Up | 0.0385646825 |
| GSE54402 | Up | 0.0293865035 |
| GSE9593 | Up | 0.1652025986 |
| GSE43922 | Up | 0.0267888006 |
| GSE24585 | Down | -0.0226026384 |
| GSE37065 | Down | -0.0723894330 |
| GSE28863_A1 | Down | -0.0866137541 |
| GSE28863_A2 | Down | -0.0152566048 |
| GSE28863_A3 | Up | 0.3450522605 |
| GSE28863_A4 | Up | 0.1501505557 |
| GSE48662 | Up | 0.1364423364 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Diclofenac | DB00586 | APRD00527 |
| Meclofenamic acid | DB00939 | APRD01090 |
| ICA-105665 | DB06089 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019416 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-375 | MIMAT0000728 | MIRT020071 | Western blot;qRT-PCR;Microarray | Functional MTI | 20584986 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030213 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
