HCSGD entry for KCNQ1

1. General information

Official gene symbolKCNQ1
Entrez ID3784
Gene full namepotassium voltage-gated channel, KQT-like subfamily, member 1
Other gene symbolsATFB1 ATFB3 JLNS1 KCNA8 KCNA9 KVLQT1 Kv1.9 Kv7.1 LQT LQT1 RWS SQT2 WRS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005249Voltage-gated potassium channel activityIDA IEAmolecular_function
GO:0005251Delayed rectifier potassium channel activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIDAmolecular_function
GO:0005764LysosomeIDAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005770Late endosomeIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006349Regulation of gene expression by genetic imprintingIEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007605Sensory perception of soundTASbiological_process
GO:0008016Regulation of heart contractionICbiological_process
GO:0008076Voltage-gated potassium channel complexIC IDA IEAcellular_component
GO:0008157Protein phosphatase 1 bindingIDAmolecular_function
GO:0008584Male gonad developmentIEAbiological_process
GO:0015271Outward rectifier potassium channel activityIEAmolecular_function
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016458Gene silencingIEAbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIDAmolecular_function
GO:0034237Protein kinase A regulatory subunit bindingIDAmolecular_function
GO:0035690Cellular response to drugIDAbiological_process
GO:0042383SarcolemmaIEAcellular_component
GO:0042589Zymogen granule membraneIEAcellular_component
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0044325Ion channel bindingIPImolecular_function
GO:0046676Negative regulation of insulin secretionIEAbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060306Regulation of membrane repolarizationIDA IMPbiological_process
GO:0060307Regulation of ventricular cardiac muscle cell membrane repolarizationIMPbiological_process
GO:0060372Regulation of atrial cardiac muscle cell membrane repolarizationIMPbiological_process
GO:0060454Positive regulation of gastric acid secretionIEAbiological_process
GO:0071320Cellular response to cAMPIDAbiological_process
GO:0071435Potassium ion exportIDAbiological_process
GO:0071805Potassium ion transmembrane transportIDAbiological_process
GO:0071872Cellular response to epinephrine stimulusTASbiological_process
GO:0072358Cardiovascular system developmentIEAbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIMPbiological_process
GO:0086008Voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarizationIMPmolecular_function
GO:0086011Membrane repolarization during action potentialIDAbiological_process
GO:0086013Membrane repolarization during cardiac muscle cell action potentialIMP TASbiological_process
GO:0086014Atrial cardiac muscle cell action potentialIMPbiological_process
GO:0086089Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarizationIMPmolecular_function
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:0097110Scaffold protein bindingIPImolecular_function
GO:1901381Positive regulation of potassium ion transmembrane transportIDAbiological_process
GO:1902282Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationIMPmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42704301510.92295521070.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0828834448
GSE13712_SHEARUp0.0345140032
GSE13712_STATICUp0.1311438007
GSE19018Up0.1222876539
GSE19899_A1Up0.0486120129
GSE19899_A2Up0.1819861648
PubMed_21979375_A1Up0.0733385443
PubMed_21979375_A2Up0.0300390370
GSE35957Up0.0352875868
GSE36640Up0.0230546734
GSE54402Up0.1196407289
GSE9593Down-0.1261835603
GSE43922Up0.1518226481
GSE24585Down-0.0148954260
GSE37065Down-0.0232485601
GSE28863_A1Down-0.0855488072
GSE28863_A2Down-0.0510976252
GSE28863_A3Up0.3947971110
GSE28863_A4Up0.1265185964
GSE48662Down-0.0002107615

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IndapamideDB00808 APRD01031
BepridilDB01244 APRD00727
AzimilideDB04957 -
ICA-105665DB06089 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-133a-3pMIMAT0000427MIRT002925Luciferase reporter assay//Western blot//5'RACE//Real time RT-PCRFunctional MTI17443681
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.