HCSGD entry for KCNN4

1. General information

Official gene symbolKCNN4
Entrez ID3783
Gene full namepotassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Other gene symbolsIK1 IKCA1 KCA4 KCa3.1 SK4 hIKCa1 hKCa4 hSK4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002376Immune system processIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006813Potassium ion transportTASbiological_process
GO:0006816Calcium ion transportIDAbiological_process
GO:0006884Cell volume homeostasisIEAbiological_process
GO:0006952Defense responseTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008076Voltage-gated potassium channel complexICcellular_component
GO:0015269Calcium-activated potassium channel activityIDAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0016286Small conductance calcium-activated potassium channel activityIEAmolecular_function
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0022894Intermediate conductance calcium-activated potassium channel activityIEAmolecular_function
GO:0030322Stabilization of membrane potentialIDAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0045121Membrane raftIEAcellular_component
GO:0045332Phospholipid translocationIEAbiological_process
GO:0046541Saliva secretionIEAbiological_process
GO:0050714Positive regulation of protein secretionIEAbiological_process
GO:0050862Positive regulation of T cell receptor signaling pathwayIDAbiological_process
GO:0071435Potassium ion exportIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30275108090.26212509780.99999024730.9832189655

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2413611640
GSE13712_SHEARDown-1.5102007159
GSE13712_STATICUp0.3349494844
GSE19018Down-0.0176122801
GSE19899_A1Up0.0072533983
GSE19899_A2Up0.1905887196
PubMed_21979375_A1Down-0.3994627577
PubMed_21979375_A2Up0.0662710033
GSE35957Down-0.7575723452
GSE36640Down-0.0301265745
GSE54402Up0.1754405404
GSE9593Up0.1002710423
GSE43922Up0.0746473356
GSE24585Down-0.0481185384
GSE37065Up0.2366287433
GSE28863_A1Down-0.5799517570
GSE28863_A2Down-0.0950613919
GSE28863_A3Up0.1771702128
GSE28863_A4Up0.2227134077
GSE48662Up0.2862350998

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

EnfluraneDB00228 APRD00234
QuinineDB00468 APRD00563
MiconazoleDB01110 APRD01115

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT001448pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-375MIMAT0000728MIRT019994MicroarrayFunctional MTI (Weak)20215506
hsa-miR-1MIMAT0000416MIRT024000ProteomicsFunctional MTI (Weak)18668040
hsa-miR-30a-5pMIMAT0000087MIRT028637ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.