HCSGD entry for KCNMA1

1. General information

Official gene symbolKCNMA1
Entrez ID3778
Gene full namepotassium large conductance calcium-activated channel, subfamily M, alpha member 1
Other gene symbolsBKTM KCa1.1 MaxiK SAKCA SLO SLO-ALPHA SLO1 bA205K10.1 mSLO1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIDAbiological_process
GO:0003779Actin bindingIDAmolecular_function
GO:0005249Voltage-gated potassium channel activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005901CaveolaIDAcellular_component
GO:0006810TransportIDAbiological_process
GO:0006812Cation transportIDAbiological_process
GO:0006813Potassium ion transportIDAbiological_process
GO:0006970Response to osmotic stressIDAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008076Voltage-gated potassium channel complexIDAcellular_component
GO:0009897External side of plasma membraneIEAcellular_component
GO:0015269Calcium-activated potassium channel activityIDAmolecular_function
GO:0015672Monovalent inorganic cation transportIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIDA IEAcellular_component
GO:0016324Apical plasma membraneIDAcellular_component
GO:0019228Neuronal action potentialIEAbiological_process
GO:0030001Metal ion transportIDAbiological_process
GO:0030007Cellular potassium ion homeostasisIDAbiological_process
GO:0032344Regulation of aldosterone metabolic processIEAbiological_process
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0034465Response to carbon monoxideIDA IMPbiological_process
GO:0034765Regulation of ion transmembrane transportIDAbiological_process
GO:0042391Regulation of membrane potentialIDAbiological_process
GO:0042491Auditory receptor cell differentiationIEAbiological_process
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043195Terminal boutonIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045475Locomotor rhythmIEAbiological_process
GO:0045794Negative regulation of cell volumeIDAbiological_process
GO:0046541Saliva secretionIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048469Cell maturationIEAbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0051049Regulation of transportIDAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051592Response to calcium ionIDAbiological_process
GO:0055085Transmembrane transportIDAbiological_process
GO:0060072Large conductance calcium-activated potassium channel activityIDA IEA IMPmolecular_function
GO:0060073MicturitionIDAbiological_process
GO:0060082Eye blink reflexIEAbiological_process
GO:0060083Smooth muscle contraction involved in micturitionIDAbiological_process
GO:0060087Relaxation of vascular smooth muscleIEAbiological_process
GO:0071805Potassium ion transmembrane transportIBA IDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15029136050.40335265760.77504288791.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1555757660
GSE13712_SHEARDown-0.1567898306
GSE13712_STATICDown-0.0661634191
GSE19018Up0.9811407450
GSE19899_A1Up0.2111221775
GSE19899_A2Down-0.9152478874
PubMed_21979375_A1Down-0.4449466283
PubMed_21979375_A2Up0.1745512346
GSE35957Up0.0633928862
GSE36640Up0.8276203197
GSE54402Up0.4188252186
GSE9593Up0.5100550038
GSE43922Down-0.0527682965
GSE24585Down-0.0996341389
GSE37065Up0.0735258535
GSE28863_A1Down-0.1163210399
GSE28863_A2Up0.3690329564
GSE28863_A3Down-0.1972421577
GSE28863_A4Down-0.1644790521
GSE48662Down-0.1809134913

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BendroflumethiazideDB00436 APRD00666
HydroflumethiazideDB00774 APRD01020
HydrochlorothiazideDB00999 APRD00092
Cromoglicic acidDB01003 APRD00336
MiconazoleDB01110 APRD01115
DiazoxideDB01119 APRD00914

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-211-5pMIMAT0000268MIRT005943Microarray//LacZ reporter assayFunctional MTI21072171
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16563376Here, we report a new approach to the study of recycling from the phagosomal compartment: streptolysin O- (SLO) permeabilized macrophages
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