HCSGD entry for KCNJ11

1. General information

Official gene symbol	KCNJ11
Entrez ID	3767
Gene full name	potassium inwardly-rectifying channel, subfamily J, member 11
Other gene symbols	BIR HHF2 IKATP KIR6.2 PHHI TNDM3
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0002931	Response to ischemia	IEA	biological_process
GO:0005249	Voltage-gated potassium channel activity	IDA	molecular_function
GO:0005524	ATP binding	IEA ISS	molecular_function
GO:0005635	Nuclear envelope	IEA	cellular_component
GO:0005739	Mitochondrion	IEA	cellular_component
GO:0005768	Endosome	IEA	cellular_component
GO:0005783	Endoplasmic reticulum	IEA	cellular_component
GO:0005829	Cytosol	IEA	cellular_component
GO:0005886	Plasma membrane	IDA TAS	cellular_component
GO:0005887	Integral component of plasma membrane	TAS	cellular_component
GO:0006006	Glucose metabolic process	IMP	biological_process
GO:0006112	Energy reserve metabolic process	TAS	biological_process
GO:0007268	Synaptic transmission	TAS	biological_process
GO:0008022	Protein C-terminus binding	IEA	molecular_function
GO:0008076	Voltage-gated potassium channel complex	IDA	cellular_component
GO:0008282	ATP-sensitive potassium channel complex	IDA IEA ISS	cellular_component
GO:0010107	Potassium ion import	IEA ISS	biological_process
GO:0014704	Intercalated disc	IEA	cellular_component
GO:0015272	ATP-activated inward rectifier potassium channel activity	IEA ISS	molecular_function
GO:0016021	Integral component of membrane	IEA	cellular_component
GO:0030315	T-tubule	IEA ISS	cellular_component
GO:0030506	Ankyrin binding	IEA IPI	molecular_function
GO:0030673	Axolemma	IEA	cellular_component
GO:0030955	Potassium ion binding	TAS	molecular_function
GO:0031072	Heat shock protein binding	IEA	molecular_function
GO:0032355	Response to estradiol	IEA	biological_process
GO:0033198	Response to ATP	IDA	biological_process
GO:0033574	Response to testosterone	IEA	biological_process
GO:0042391	Regulation of membrane potential	IDA	biological_process
GO:0042493	Response to drug	IEA IMP	biological_process
GO:0043025	Neuronal cell body	IEA	cellular_component
GO:0043209	Myelin sheath	IEA	cellular_component
GO:0044281	Small molecule metabolic process	TAS	biological_process
GO:0044325	Ion channel binding	IPI	molecular_function
GO:0046676	Negative regulation of insulin secretion	IMP	biological_process
GO:0050796	Regulation of insulin secretion	IMP TAS	biological_process
GO:0050877	Neurological system process	IMP	biological_process
GO:0070852	Cell body fiber	IEA	cellular_component
GO:0071316	Cellular response to nicotine	IEA	biological_process
GO:0071333	Cellular response to glucose stimulus	IEA	biological_process
GO:0071356	Cellular response to tumor necrosis factor	IEA	biological_process
GO:0071805	Potassium ion transmembrane transport	IDA	biological_process
GO:2001259	Positive regulation of cation channel activity	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.6186933855	0.6255227309	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.1456073718
GSE13712_SHEAR	Up	0.0930191641
GSE13712_STATIC	Down	-0.0158249818
GSE19018	Up	0.2221024253
GSE19899_A1	Up	0.0275848688
GSE19899_A2	Up	0.1210376622
PubMed_21979375_A1	Up	0.0658556460
PubMed_21979375_A2	Up	0.2674137655
GSE35957	Up	0.2252741271
GSE36640	Down	-0.0703189048
GSE54402	Down	-0.1551471885
GSE9593	Down	-0.0641181175
GSE43922	Up	0.0517626111
GSE24585	Down	-0.3393354164
GSE37065	Up	0.0317947150
GSE28863_A1	Down	-0.0182402811
GSE28863_A2	Down	-0.1947225203
GSE28863_A3	Up	0.1946169567
GSE28863_A4	Up	0.1567842193
GSE48662	Down	-0.0769402863

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Glimepiride	DB00222	APRD00381
Ibutilide	DB00308	APRD01025
Verapamil	DB00661	APRD00335
Levosimendan	DB00922	APRD01296
Diazoxide	DB01119	APRD00914

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for KCNJ11

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )