HCSGD entry for AGRN

1. General information

Official gene symbolAGRN
Entrez ID375790
Gene full nameagrin
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0002162Dystroglycan bindingISSmolecular_function
GO:0005200Structural constituent of cytoskeletonTASmolecular_function
GO:0005509Calcium ion bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005605Basal laminaIDAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006024Glycosaminoglycan biosynthetic processTASbiological_process
GO:0006027Glycosaminoglycan catabolic processTASbiological_process
GO:0007009Plasma membrane organizationIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007213G-protein coupled acetylcholine receptor signaling pathwayTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007528Neuromuscular junction developmentIEAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030203Glycosaminoglycan metabolic processTASbiological_process
GO:0030204Chondroitin sulfate metabolic processTASbiological_process
GO:0030548Acetylcholine receptor regulator activityIEAmolecular_function
GO:0031012Extracellular matrixIDA TAScellular_component
GO:0032321Positive regulation of Rho GTPase activityISSbiological_process
GO:0033691Sialic acid bindingISSmolecular_function
GO:0035374Chondroitin sulfate bindingISSmolecular_function
GO:0043113Receptor clusteringIDA IMPbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0043236Laminin bindingTASmolecular_function
GO:0043395Heparan sulfate proteoglycan bindingISSmolecular_function
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045162Clustering of voltage-gated sodium channelsTASbiological_process
GO:0045202SynapseISScellular_component
GO:0045213Neurotransmitter receptor metabolic processIEAbiological_process
GO:0045887Positive regulation of synaptic growth at neuromuscular junctionISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0050808Synapse organizationTASbiological_process
GO:0051491Positive regulation of filopodium assemblyISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09949057410.70754640400.65845898921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1502185453
GSE13712_SHEARUp0.2931755633
GSE13712_STATICUp0.5719860481
GSE19018Up0.5599255766
GSE19899_A1Down-0.2087021810
GSE19899_A2Down-0.0052257603
PubMed_21979375_A1Down-0.0654766754
PubMed_21979375_A2Up0.2288793972
GSE35957Down-0.7391473394
GSE36640Down-0.0368202141
GSE54402Down-0.2825605251
GSE9593Up0.1150880932
GSE43922Up0.0009589457
GSE24585Up0.1067663167
GSE37065Up0.2779615516
GSE28863_A1Up0.1877964736
GSE28863_A2Up0.6372722393
GSE28863_A3Up0.2384553580
GSE28863_A4Down-0.0219437843
GSE48662Up0.6107672389

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT001391pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-155-5pMIMAT0000646MIRT020958ProteomicsFunctional MTI (Weak)17881434
hsa-miR-16-5pMIMAT0000069MIRT031889ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.