HCSGD entry for KCNA5

1. General information

Official gene symbolKCNA5
Entrez ID3741
Gene full namepotassium voltage-gated channel, shaker-related subfamily, member 5
Other gene symbolsATFB7 HCK1 HK2 HPCN1 KV1.5 PCN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0005102Receptor bindingIEAmolecular_function
GO:0005251Delayed rectifier potassium channel activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005901CaveolaTAScellular_component
GO:0006813Potassium ion transportIDAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008076Voltage-gated potassium channel complexIDAcellular_component
GO:0014704Intercalated discIDAcellular_component
GO:0015271Outward rectifier potassium channel activityIDA IMPmolecular_function
GO:0019229Regulation of vasoconstrictionIEAbiological_process
GO:0019870Potassium channel inhibitor activityIEAmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030018Z discIEAcellular_component
GO:0042391Regulation of membrane potentialIDAbiological_process
GO:0043266Regulation of potassium ion transportIMPbiological_process
GO:0043267Negative regulation of potassium ion transportIEAbiological_process
GO:0045121Membrane raftIDAcellular_component
GO:0046691Intracellular canaliculusIEAcellular_component
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051393Alpha-actinin bindingIPImolecular_function
GO:0051481Negative regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0055075Potassium ion homeostasisIEAbiological_process
GO:0060081Membrane hyperpolarizationIMPbiological_process
GO:0060372Regulation of atrial cardiac muscle cell membrane repolarizationIMPbiological_process
GO:0071435Potassium ion exportIDA IMPbiological_process
GO:0086013Membrane repolarization during cardiac muscle cell action potentialIMPbiological_process
GO:0086014Atrial cardiac muscle cell action potentialIMPbiological_process
GO:0086089Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarizationIMPmolecular_function
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:0097110Scaffold protein bindingIPImolecular_function
GO:1900087Positive regulation of G1/S transition of mitotic cell cycleIEAbiological_process
GO:2000288Positive regulation of myoblast proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49323092210.89168130010.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0672614509
GSE13712_SHEARUp0.2761206982
GSE13712_STATICUp0.1248746944
GSE19018Up0.2637774617
GSE19899_A1Up0.1323707828
GSE19899_A2Up0.1991261415
PubMed_21979375_A1Up0.2625038925
PubMed_21979375_A2Up0.0884349350
GSE35957Up0.1799859168
GSE36640Down-0.0314178112
GSE54402Down-0.0321314267
GSE9593Down-0.0326047934
GSE43922Up0.0151224101
GSE24585Down-0.0546432336
GSE37065Down-0.1549440022
GSE28863_A1Down-0.0693777365
GSE28863_A2Up0.0216729856
GSE28863_A3Up0.1251870725
GSE28863_A4Up0.0541982049
GSE48662Down-0.0203204055

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DalfampridineDB06637 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030147MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.