HCSGD entry for KARS
1. General information
| Official gene symbol | KARS |
|---|---|
| Entrez ID | 3735 |
| Gene full name | lysyl-tRNA synthetase |
| Other gene symbols | CMTRIB KARS1 KARS2 KRS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | IEA NAS | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0004824 | Lysine-tRNA ligase activity | IDA IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006430 | Lysyl-tRNA aminoacylation | IDA IEA | biological_process |
| GO:0008033 | TRNA processing | NAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0015966 | Diadenosine tetraphosphate biosynthetic process | IEA | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016597 | Amino acid binding | IEA | molecular_function |
| GO:0017101 | Aminoacyl-tRNA synthetase multienzyme complex | IEA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5072800615 | 0.3234823411 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3530796754 |
| GSE13712_SHEAR | Down | -0.0839124318 |
| GSE13712_STATIC | Up | 0.0334624960 |
| GSE19018 | Down | -0.2459407929 |
| GSE19899_A1 | Up | 0.0676189326 |
| GSE19899_A2 | Up | 0.0170864870 |
| PubMed_21979375_A1 | Up | 0.4341593492 |
| PubMed_21979375_A2 | Down | -0.0568509035 |
| GSE35957 | Down | -0.3123260504 |
| GSE36640 | Down | -0.4614081391 |
| GSE54402 | Up | 0.2261565917 |
| GSE9593 | Down | -0.2719579572 |
| GSE43922 | Down | -0.0456275892 |
| GSE24585 | Down | -0.2763957422 |
| GSE37065 | Down | -0.1158318921 |
| GSE28863_A1 | Up | 0.4358224159 |
| GSE28863_A2 | Up | 0.2571126534 |
| GSE28863_A3 | Up | 0.1894027319 |
| GSE28863_A4 | Up | 0.1569426601 |
| GSE48662 | Down | -0.8118950830 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Lysine | DB00123 | NUTR00037 | DB11101 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036417 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042065 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
