HCSGD entry for JAK2
1. General information
| Official gene symbol | JAK2 |
|---|---|
| Entrez ID | 3717 |
| Gene full name | Janus kinase 2 |
| Other gene symbols | JTK10 THCYT3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | IEA | biological_process |
| GO:0004672 | Protein kinase activity | NAS | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | EXP ISS TAS | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005131 | Growth hormone receptor binding | IEA ISS | molecular_function |
| GO:0005143 | Interleukin-12 receptor binding | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005901 | Caveola | IEA ISS | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0006915 | Apoptotic process | ISS | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | ISS | biological_process |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0007165 | Signal transduction | ISS | biological_process |
| GO:0007167 | Enzyme linked receptor protein signaling pathway | ISS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | IEA | biological_process |
| GO:0007259 | JAK-STAT cascade | TAS | biological_process |
| GO:0007260 | Tyrosine phosphorylation of STAT protein | ISS | biological_process |
| GO:0007262 | STAT protein import into nucleus | IEA ISS | biological_process |
| GO:0007498 | Mesoderm development | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IEA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA ISS | biological_process |
| GO:0008631 | Intrinsic apoptotic signaling pathway in response to oxidative stress | IEA | biological_process |
| GO:0009755 | Hormone-mediated signaling pathway | IEA | biological_process |
| GO:0010811 | Positive regulation of cell-substrate adhesion | IDA | biological_process |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | ISS | biological_process |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | ISS | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | IDA ISS TAS | biological_process |
| GO:0019901 | Protein kinase binding | IDA | molecular_function |
| GO:0020037 | Heme binding | IDA | molecular_function |
| GO:0022408 | Negative regulation of cell-cell adhesion | IEA | biological_process |
| GO:0030041 | Actin filament polymerization | NAS | biological_process |
| GO:0030099 | Myeloid cell differentiation | IEA | biological_process |
| GO:0030154 | Cell differentiation | ISS | biological_process |
| GO:0030218 | Erythrocyte differentiation | ISS | biological_process |
| GO:0030335 | Positive regulation of cell migration | IEA | biological_process |
| GO:0031103 | Axon regeneration | IEA | biological_process |
| GO:0031702 | Type 1 angiotensin receptor binding | IEA | molecular_function |
| GO:0031904 | Endosome lumen | TAS | cellular_component |
| GO:0031959 | Mineralocorticoid receptor signaling pathway | IEA | biological_process |
| GO:0032024 | Positive regulation of insulin secretion | IEA | biological_process |
| GO:0032496 | Response to lipopolysaccharide | ISS | biological_process |
| GO:0032516 | Positive regulation of phosphoprotein phosphatase activity | IEA | biological_process |
| GO:0032731 | Positive regulation of interleukin-1 beta production | IEA | biological_process |
| GO:0032760 | Positive regulation of tumor necrosis factor production | ISS | biological_process |
| GO:0033130 | Acetylcholine receptor binding | IEA | molecular_function |
| GO:0033160 | Positive regulation of protein import into nucleus, translocation | IEA | biological_process |
| GO:0033194 | Response to hydroperoxide | IEA | biological_process |
| GO:0033209 | Tumor necrosis factor-mediated signaling pathway | IDA | biological_process |
| GO:0034050 | Host programmed cell death induced by symbiont | IEA | biological_process |
| GO:0034612 | Response to tumor necrosis factor | IDA | biological_process |
| GO:0035401 | Histone kinase activity (H3-Y41 specific) | IDA | molecular_function |
| GO:0035409 | Histone H3-Y41 phosphorylation | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | ISS | biological_process |
| GO:0035722 | Interleukin-12-mediated signaling pathway | IDA | biological_process |
| GO:0042169 | SH2 domain binding | IPI | molecular_function |
| GO:0042393 | Histone binding | IDA IEA | molecular_function |
| GO:0042503 | Tyrosine phosphorylation of Stat3 protein | IEA | biological_process |
| GO:0042506 | Tyrosine phosphorylation of Stat5 protein | IEA | biological_process |
| GO:0042508 | Tyrosine phosphorylation of Stat1 protein | IEA | biological_process |
| GO:0042517 | Positive regulation of tyrosine phosphorylation of Stat3 protein | ISS | biological_process |
| GO:0042523 | Positive regulation of tyrosine phosphorylation of Stat5 protein | ISS | biological_process |
| GO:0042977 | Activation of JAK2 kinase activity | ISS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0043388 | Positive regulation of DNA binding | IEA | biological_process |
| GO:0043392 | Negative regulation of DNA binding | IEA ISS | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0043548 | Phosphatidylinositol 3-kinase binding | IEA | molecular_function |
| GO:0043560 | Insulin receptor substrate binding | IEA | molecular_function |
| GO:0045121 | Membrane raft | ISS | cellular_component |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | IEA | biological_process |
| GO:0045597 | Positive regulation of cell differentiation | IEA | biological_process |
| GO:0045822 | Negative regulation of heart contraction | IEA | biological_process |
| GO:0046677 | Response to antibiotic | IDA | biological_process |
| GO:0046777 | Protein autophosphorylation | ISS | biological_process |
| GO:0048008 | Platelet-derived growth factor receptor signaling pathway | IEA | biological_process |
| GO:0050727 | Regulation of inflammatory response | IDA | biological_process |
| GO:0050729 | Positive regulation of inflammatory response | IEA | biological_process |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | ISS | biological_process |
| GO:0050867 | Positive regulation of cell activation | IEA | biological_process |
| GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | IEA | biological_process |
| GO:0051428 | Peptide hormone receptor binding | IEA | molecular_function |
| GO:0051770 | Positive regulation of nitric-oxide synthase biosynthetic process | IEA ISS | biological_process |
| GO:0060333 | Interferon-gamma-mediated signaling pathway | IEA TAS | biological_process |
| GO:0060334 | Regulation of interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0060396 | Growth hormone receptor signaling pathway | IDA | biological_process |
| GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | ISS TAS | biological_process |
| GO:0060399 | Positive regulation of growth hormone receptor signaling pathway | ISS | biological_process |
| GO:0061180 | Mammary gland epithelium development | IEA ISS | biological_process |
| GO:0070671 | Response to interleukin-12 | IDA | biological_process |
| GO:0097191 | Extrinsic apoptotic signaling pathway | IEA ISS | biological_process |
| GO:0097296 | Activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | ISS | biological_process |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8694566848 | 0.0842181300 | 0.9999902473 | 0.5513778413 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2096839833 |
| GSE13712_SHEAR | Up | 0.0136398350 |
| GSE13712_STATIC | Up | 0.1874524197 |
| GSE19018 | Down | -0.2345759352 |
| GSE19899_A1 | Up | 0.0837004331 |
| GSE19899_A2 | Down | -1.1676215010 |
| PubMed_21979375_A1 | Down | -0.0408396715 |
| PubMed_21979375_A2 | Down | -0.6274231168 |
| GSE35957 | Down | -0.9609100860 |
| GSE36640 | Down | -0.0233535341 |
| GSE54402 | Down | -0.3224604855 |
| GSE9593 | Up | 0.3057867994 |
| GSE43922 | Down | -0.0489991719 |
| GSE24585 | Down | -0.1652604066 |
| GSE37065 | Up | 0.4073094056 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.4088961268 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE | DB04716 | - |
| XL019 | DB05243 | - |
| 5-phenyl-1H-indazol-3-amine | DB07161 | - |
| 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide | DB07162 | - |
| 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM | DB08067 | - |
| 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | DB08183 | - |
| Ruxolitinib | DB08877 | - |
| Tofacitinib | DB08895 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-135a-5p | MIMAT0000428 | MIRT000707 | Luciferase reporter assay//Western blot | Functional MTI | 19666866 |
| hsa-miR-375 | MIMAT0000728 | MIRT001749 | Luciferase reporter assay//Western blot//Reporter assay;Western blot | Functional MTI | 20548334 |
| hsa-miR-375 | MIMAT0000728 | MIRT001749 | Reporter assay | Functional MTI | 15806104 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017973 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT044858 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051067 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-135a-5p | MIMAT0000428 | 1 | hsa-miR-135a | {Western blot} | {overexpression by miRNA precursor transfection} | 19666866 | |
| hsa-miR-375 | MIMAT0000728 | 1 | hsa-miR-375 | {Western blot} | {overexpression by miRNA precursor transfection} | 20548334 | |
| hsa-miR-375 | MIMAT0000728 | 2 | hsa-miR-375 | {Western blot} | {overexpression by miRNA precursor transfection} | 20548334 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23897841 | Instead, the prompt inhibition of Janus kinase 2 (Jak2), tyrosine kinase 2 (Tyk2), and signal transducer and activator of transcription 3 (Stat3) activation was observed in cells undergoing senescence |
| 21472252 | Role of the JAK2/STAT pathway and losartan in human glomerular mesangial cell senescence |
| 21472252 | The JAK2/STAT pathway plays a pivotal role in transmitting cytokine signals |
| 21472252 | Therefore, this study was designed to determine the effects of AngII and the JAK2/STAT pathway on the process of GMC aging |
| 21472252 | We observed the functions of the AngII receptor blocker losartan and the JAK2 blocker AG490 in delaying GMC aging |
| 21472252 | The JAK2/STAT1/3 pathway is drastically activated in AngII-induced senescence cells |
| 21472252 | Our results suggest that AngII induces human GMC senescence, and that the JAK2/STAT1/3 pathway is involved in this process |
| 21472252 | By applying losartan and blocking the JAK2/STAT pathway, it may be possible to delay GMC aging |
| 18084761 | One direct transcriptional activator of hTERT is the oncogene MYC which is known to be, in turn, activated by JAK2 |
| 18084761 | To explore the relationship of telomerase, MYC and JAK2 in chronic myeloproliferative diseases, we investigated hTERT and MYC expression in bone marrow cells of essential thrombocythemia (ET) and polycythemia vera (PV) |
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